H
H. Ümit Kaniskan
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 50
Citations - 1791
H. Ümit Kaniskan is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 16, co-authored 35 publications receiving 791 citations. Previous affiliations of H. Ümit Kaniskan include Washington State University & Case Western Reserve University.
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Journal ArticleDOI
Inhibitors of Protein Methyltransferases and Demethylases.
TL;DR: This review covers the discovery, characterization, and biological application of inhibitors of PMTs and KDMs with emphasis on key advancements in the field and discusses challenges, opportunities, and future directions in this emerging, exciting research field.
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Advancing targeted protein degradation for cancer therapy.
TL;DR: In this paper, the molecular basis of targeted protein degradation is discussed and a comprehensive review of the most promising degraders in development as cancer therapies to date is provided, with a focus on opportunities and challenges for future development.
Journal ArticleDOI
Light-induced control of protein destruction by opto-PROTAC.
Jing Liu,He Chen,Leina Ma,Zhixiang He,Dong Wang,Yi Liu,Yi Liu,Qian Lin,Tinghu Zhang,Nathanael S. Gray,H. Ümit Kaniskan,Jian Jin,Wenyi Wei +12 more
TL;DR: This work introduces a light-inducible switch on PROTACs, thereafter termed as opto-PROTAC, to enable the degradation of protein targets in a spatiotemporal manner and enables PROTAC to be a precision medicine.
Journal ArticleDOI
Selective inhibitors of protein methyltransferases
TL;DR: A perspective on selective, small-molecule inhibitors of PMTs with an emphasis on their discovery, characterization, and applicability as chemical tools for deciphering the target PMTs’ physiological functions and involvement in human diseases is presented.
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A chemical biology toolbox to study protein methyltransferases and epigenetic signaling
Sebastian Scheer,Suzanne Ackloo,Tiago Medina,Matthieu Schapira,Matthieu Schapira,Fengling Li,Jennifer A. Ward,Jennifer A. Ward,Andrew M. Lewis,Andrew M. Lewis,Jeffrey P. Northrop,Paul L. Richardson,H. Ümit Kaniskan,Yudao Shen,Jing Liu,David Smil,David McLeod,Carlos Zepeda-Velázquez,Minkui Luo,Minkui Luo,Jian Jin,Dalia Barsyte-Lovejoy,Kilian Huber,Kilian Huber,Daniel D. De Carvalho,Daniel D. De Carvalho,Masoud Vedadi,Masoud Vedadi,Colby Zaph,Peter Brown,Cheryl H. Arrowsmith,Cheryl H. Arrowsmith,Cheryl H. Arrowsmith +32 more
TL;DR: A collection of chemical probes and associated reagents and data are presented to elucidate the function of human and murine PMTs in cellular studies, and a role for DOT1L in limiting Th1 cell differentiation and maintaining lineage integrity is demonstrated.