H
Hagop Youssoufian
Researcher at Baylor College of Medicine
Publications - 65
Citations - 3386
Hagop Youssoufian is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Fanconi anemia & Duvelisib. The author has an hindex of 27, co-authored 65 publications receiving 3235 citations. Previous affiliations of Hagop Youssoufian include University of Amsterdam & ImClone Systems.
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Journal ArticleDOI
Cancer predisposition caused by elevated mitotic recombination in Bloom mice
Guangbin Luo,Irma M. Santoro,Lisa D. McDaniel,Ichiko Nishijima,Michael Mills,Hagop Youssoufian,Hannes Vogel,Roger A. Schultz,Allan Bradley,Allan Bradley +9 more
TL;DR: It is demonstrated that the increased rate of loss of heterozygosity (LOH) resulting from mitotic recombination in vivo constitutes the underlying mechanism causing tumour susceptibility in these mice.
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Structure, function, and activation of the erythropoietin receptor.
TL;DR: Recent studies on the structure, function, and activation of the EPO-R receptor are described, with a focus on mechanisms by which the activated receptor can induce cellular proliferation in the absence of EPO.
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Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia.
Ming Chen,Darrell J. Tomkins,Wojtek Auerbach,Colin McKerlie,Hagop Youssoufian,Lili Liu,Olga I. Gan,Madeleine Carreau,Anna Auerbach,Tim Groves,Cynthia J. Guidos,Melvin H. Freedman,Jay Cross,Jay Cross,Dean H. Percy,John E. Dick,Alexandra L. Joyner,Manuel Buchwald +17 more
TL;DR: Inactivation of Fac replicates some of the features of the human disease, leading to markedly impaired fertility, a characteristic of FA patients.
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Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1.
Robert C. Cumming,Jeff Lightfoot,Kristin Beard,Hagop Youssoufian,Peter J. O'Brien,Manuel Buchwald +5 more
TL;DR: It is shown that glutathione S-transferase P1-1 (GSTP1) interacts with FANCC, and that overexpression of both proteins in a myeloid progenitor cell line prevents apoptosis following factor deprivation.
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Abnormal Microsomal Detoxification Implicated in Fanconi Anemia Group C by Interaction of the FAC Protein With NADPH Cytochrome P450 Reductase
Frank A.E. Kruyt,Taizo Hoshino,Taizo Hoshino,Johnson M. Liu,Johnson M. Liu,Pius Joseph,Pius Joseph,Anil K. Jaiswal,Anil K. Jaiswal,Hagop Youssoufian,Hagop Youssoufian +10 more
TL;DR: FAC binds to NADPH cytochrome-P450 reductase (RED), a microsomal membrane protein involved in electron transfer, in both transfected COS-1 and normal murine liver cells, and is proposed to play a fundamental role in vivo by attenuating the activity of RED, thereby regulating a major detoxification pathway in mammalian cells.