H
Hai-Ning Chen
Researcher at Sichuan University
Publications - 69
Citations - 1942
Hai-Ning Chen is an academic researcher from Sichuan University. The author has contributed to research in topics: Metastasis & Cancer. The author has an hindex of 21, co-authored 57 publications receiving 1186 citations.
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Journal ArticleDOI
Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer.
Qianhui Dou,Hai-Ning Chen,Kui Wang,Kefei Yuan,Yunlong Lei,Kai Li,Jiang Lan,Yan Chen,Zhao Huang,Na Xie,Lu Zhang,Rong Xiang,Edouard C. Nice,Yuquan Wei,Canhua Huang,Canhua Huang +15 more
TL;DR: A role for ivermectin in breast cancer suppression by activating cytostatic autophagy both in vitro and in vivo is reported and it is indicated that iver mectin is a potential option for the treatment of breast cancer.
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Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: evidence from a meta-analysis
TL;DR: It is suggested that patients with Intestinal metaplasia or dysplasia could not benefit from the H. pylori treatment on the risk of GC, according to a meta-analysis of randomized controlled trials.
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Redox regulation in tumor cell epithelial–mesenchymal transition: Molecular basis and therapeutic strategy
TL;DR: Recent advances in redox biology involved in the EMT process in cancer cells are addressed, which will contribute to the development of novel therapeutic strategies by targeting redox-regulated EMT for cancer treatment.
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Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma.
Yan Chen,Hai-Ning Chen,Kui Wang,Lu Zhang,Zhao Huang,Jiayang Liu,Zhe Zhang,Maochao Luo,Yunlong Lei,Yong Peng,Zong-Guang Zhou,Yuquan Wei,Canhua Huang +12 more
TL;DR: The study reveals that ketoconazole, a broad-spectrum antifungal agent, activates PINK1/Parkin-mediated mitophagy by downregulating COX-2, consequently resulting in the acceleration of apoptosis and thereby inhibiting the growth of HCC.
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PDLIM1 Stabilizes the E-Cadherin/β-Catenin Complex to Prevent Epithelial-Mesenchymal Transition and Metastatic Potential of Colorectal Cancer Cells.
Hai-Ning Chen,Kefei Yuan,Na Xie,Kui Wang,Zhao Huang,Yan Chen,Qianhui Dou,Min Wu,Edouard C. Nice,Zong-Guang Zhou,Canhua Huang +10 more
TL;DR: This study demonstrates that PDLIM1 suppresses EMT and metastatic potential of colorectal cancer cells by stabilizing β-catenin at cell-cell junctions, and its loss in metastatic tissues may represent a potential prognostic marker of aggressive disease.