Z
Zhao Huang
Researcher at Sichuan University
Publications - 52
Citations - 1510
Zhao Huang is an academic researcher from Sichuan University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 13, co-authored 20 publications receiving 612 citations. Previous affiliations of Zhao Huang include Chinese Ministry of Education.
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Journal ArticleDOI
The role of long noncoding RNAs in hepatocellular carcinoma.
TL;DR: A deeper understanding of lncRNA dysregulation would provide new insights into HCC pathogenesis and novel tools for the early diagnosis and treatment of HCC.
Journal ArticleDOI
Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer.
Qianhui Dou,Hai-Ning Chen,Kui Wang,Kefei Yuan,Yunlong Lei,Kai Li,Jiang Lan,Yan Chen,Zhao Huang,Na Xie,Lu Zhang,Rong Xiang,Edouard C. Nice,Yuquan Wei,Canhua Huang,Canhua Huang +15 more
TL;DR: A role for ivermectin in breast cancer suppression by activating cytostatic autophagy both in vitro and in vivo is reported and it is indicated that iver mectin is a potential option for the treatment of breast cancer.
Journal ArticleDOI
From purines to purinergic signalling: molecular functions and human diseases.
Zhao Huang,Na Xie,Peter Illes,Peter Illes,Francesco Di Virgilio,Henning Ulrich,Henning Ulrich,Alexey Semyanov,Alexey Semyanov,Alexei Verkhratsky,Alexei Verkhratsky,Alexei Verkhratsky,Beáta Sperlágh,Shu-Guang Yu,Canhua Huang,Canhua Huang,Yong Tang +16 more
TL;DR: In this paper, a molecular understanding of molecular mechanisms of purinergic signalling provides new and exciting insights into the treatment of human diseases such as neurodegeneration, rheumatic immune diseases, inflammation, and cancer.
Journal ArticleDOI
Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma.
Yan Chen,Hai-Ning Chen,Kui Wang,Lu Zhang,Zhao Huang,Jiayang Liu,Zhe Zhang,Maochao Luo,Yunlong Lei,Yong Peng,Zong-Guang Zhou,Yuquan Wei,Canhua Huang +12 more
TL;DR: The study reveals that ketoconazole, a broad-spectrum antifungal agent, activates PINK1/Parkin-mediated mitophagy by downregulating COX-2, consequently resulting in the acceleration of apoptosis and thereby inhibiting the growth of HCC.
Journal ArticleDOI
Stress management by autophagy: Implications for chemoresistance.
TL;DR: In this article, the role of autophagy in chemoresistance was defined and the mechanisms involved were investigated to enhance the efficiency of chemotherapy and develop novel anticancer strategy interventions.