Haining Liu

TL;DR: Biochemical and cellular evidence is provided that artemisinins are potent inhibitors of Plasmodium falciparum phosphatidylinositol-3-kinase (PfPI3K), revealing an unexpected mechanism of action and present PI3P as the key mediator of art Artemisinin resistance and the sole PfPI3k as an important target for malaria elimination.

TL;DR: The B3LYP density functional combined with a self-consistent reaction field was used to explore the triplet, quintet, and septet spin-state potential energy surfaces of the multistep catalytic mechanism of AlkB to find the mechanism to be oxidative dealkylation of the damaged nucleobase.

TL;DR: In this paper, the relationship between imidazole structure and SO2 absorption was investigated using a series of IM compounds with various substituents at the 1, 2 and/or 4(5) positions of the five-membered ring.

TL;DR: Prenylated stilbenoids may be preferable alternatives to tRes due to increased bioavailability via slowed metabolism and the isoprenyl moiety of tA1 and tA3 improved binding affinity to CB2Rs.

TL;DR: The proposed multiple-instance learning approach was proven not to suffer from overfitting and to be highly competitive with classical predictive models, so it is very powerful for drug activity prediction.