R
Robert V. Stahelin
Researcher at Purdue University
Publications - 177
Citations - 8103
Robert V. Stahelin is an academic researcher from Purdue University. The author has contributed to research in topics: VP40 & Ebola virus. The author has an hindex of 51, co-authored 159 publications receiving 7277 citations. Previous affiliations of Robert V. Stahelin include University of California, Irvine & University of Illinois at Chicago.
Papers
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Journal ArticleDOI
Membrane-protein interactions in cell signaling and membrane trafficking.
Wonhwa Cho,Robert V. Stahelin +1 more
TL;DR: This review summarizes the recent progress in the understanding of how the kinetics and energetics of membrane-protein interactions are regulated during the cellular membrane targeting and activation of peripheral proteins.
Journal ArticleDOI
A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria
Alassane Mbengue,Souvik Bhattacharjee,Trupti Pandharkar,Haining Liu,Guillermina Estiu,Robert V. Stahelin,Shahir S. Rizk,Dieudonne L. Njimoh,Yana Ryan,Kesinee Chotivanich,Chea Nguon,Mehdi Ghorbal,Jose Juan Lopez-Rubio,Michael E. Pfrender,Scott J. Emrich,Narla Mohandas,Arjen M. Dondorp,Olaf Wiest,Kasturi Haldar +18 more
TL;DR: Biochemical and cellular evidence is provided that artemisinins are potent inhibitors of Plasmodium falciparum phosphatidylinositol-3-kinase (PfPI3K), revealing an unexpected mechanism of action and present PI3P as the key mediator of art Artemisinin resistance and the sole PfPI3k as an important target for malaria elimination.
Journal ArticleDOI
Binding of the PX domain of p47phox to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction
Dimitrios Karathanassis,Robert V. Stahelin,Jerónimo Bravo,Olga Perisic,Christine M Pacold,Wonhwa Cho,Roger L. Williams +6 more
TL;DR: Measurements for full‐length p47phox show that membrane interaction by the PX domain is masked by an intramolecular association with the C‐terminal SH3 domain (C‐SH3), which may cause a transition from a closed to an open conformation that binds membranes with a greater affinity than the isolated PXdomain.
Journal ArticleDOI
Membrane binding and subcellular targeting of C2 domains.
Wonhwa Cho,Robert V. Stahelin +1 more
TL;DR: This review summarizes the basic structural and functional properties of C2 domains as well as recent findings on Ca2+ and membrane binding, lipid selectivity, and subcellular localization of C1 domains and their host proteins.
Journal ArticleDOI
Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.
Sahar A. Saddoughi,Salih Gencer,Yuri K. Peterson,Katherine E. Ward,Archana Mukhopadhyay,Joshua J. Oaks,Jacek Bielawski,Zdzislaw M. Szulc,Raquela J. Thomas,Shanmugam Panneer Selvam,Can E. Senkal,Elizabeth Garrett-Mayer,Ryan M. De Palma,Dzmitry Fedarovich,Angen Liu,Amyn A. Habib,Amyn A. Habib,Robert V. Stahelin,Robert V. Stahelin,Danilo Perrotti,Besim Ogretmen +20 more
TL;DR: Data suggest that targeting I2PP2A/SET by FTY720 suppresses lung tumour growth, at least in part, via PP2A activation and necroptosis mediated by the kinase domain of RIPK1.