H
Haiyan Li
Researcher at Peking University
Publications - 27
Citations - 2265
Haiyan Li is an academic researcher from Peking University. The author has contributed to research in topics: Pharmacokinetics & Medicine. The author has an hindex of 4, co-authored 19 publications receiving 1864 citations.
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Journal ArticleDOI
In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Xueting Yao,Fei Ye,Miao Zhang,Cheng Cui,Baoying Huang,Peihua Niu,Xu Liu,Li Zhao,Erdan Dong,Chunli Song,Siyan Zhan,Roujian Lu,Haiyan Li,Wenjie Tan,Dongyang Liu +14 more
TL;DR: It is proposed that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-CoV-2 infected patients.
Journal ArticleDOI
Dose selection of chloroquine phosphate for treatment of COVID-19 based on a physiologically based pharmacokinetic model
Cheng Cui,Miao Zhang,Xueting Yao,Siqi Tu,Zhe Hou,Valerie Sia Jie En,Xiaoqiang Xiang,Jing Lin,Ting Cai,Ning Shen,Chunli Song,Jie Qiao,Shun Zhang,Haiyan Li,Dongyang Liu +14 more
TL;DR: A physiologically-based pharmacokinetic (PBPK) model, with parameterization of drug distribution extrapolated from animal data, was developed to predict human tissue distribution of CQ and successfully developed to optimize dosage regimens for patients with COVID-19.
Journal ArticleDOI
Cytotoxicity Evaluation of Chloroquine and Hydroxychloroquine in Multiple Cell Lines and Tissues by Dynamic Imaging System and Physiologically Based Pharmacokinetic Model
Jianling Yang,Zhengyang Guo,Xu Liu,Qi Liu,Meng Wu,Xueting Yao,Yang Liu,Cheng Cui,Haiyan Li,Chunli Song,Dongyang Liu,Lixiang Xue +11 more
TL;DR: Both CQ and HCQ showed cytotoxicity in time-dependent manner which indicates the necessity of short period administration clinically, and also indicates relative safety of HCQ.
Posted ContentDOI
Cytotoxicity evaluation of chloroquine and hydroxychloroquine in multiple cell lines and tissues by dynamic imaging system and PBPK model
Jianling Yang,Meng Wu,Qi Liu,Zhengyang Guo,Xueting Yao,Yang Liu,Cheng Cui,Haiyan Li,Chunli Song,Dongyang Liu,Lixiang Xue +10 more
TL;DR: Both CQ and HCQ have certain cytotoxicity in time dependent manner which indicates the necessity of short period administration clinically and the relative safety of HCQ.
Journal ArticleDOI
Development of a Physiologically Based Pharmacokinetic Model for Hydroxychloroquine and Its Application in Dose Optimization in Specific COVID-19 Patients
Miao Zhang,Xueting Yao,Zhe Hou,Xuan Guo,Siqi Tu,Zihan Lei,Zhiheng Yu,Xuanlin Liu,Cheng Cui,Xijing Chen,Ning Shen,Chunli Song,Jie Qiao,Xiaoqiang Xiang,Haiyan Li,Dongyang Liu +15 more
TL;DR: Wang et al. as mentioned in this paper developed a physiologically-based pharmacokinetic (PBPK) model of hydroxychloroquine (HCQ) and integrated in vitro anti-viral effect to support dosing design of HCQ in the treatment of COVID-19 patients in China.