Haiyan Peng

TL;DR: Fumarates suppress Th1 responses by blocking IL-12 and IL-23 production by dendritic cells via distinct pathways through distinct pathways.

TL;DR: It is suggested that encephalitogenicity of myelin-specific T cells appears to be mediated by a pathway dependent on T-bet and not necessarily pathway-specific end products, such as interferon γ and IL-17.

TL;DR: Investigation of the effects of DMF on dendritic cell (DC) maturation and subsequent DC-mediated T cell responses indicates that by suppression of both NF-κB and ERK1/2-MSK1 signaling, DMF inhibits maturation of DCs and subsequently Th1 and Th17 cell differentiation.

TL;DR: Data suggest that central IL-6 is an important mediator of social influences on stroke outcome, which is accompanied by an altered neuroinflammatory response in isolated relative to socially housed mice.

TL;DR: The present data demonstrate that LIG significantly prevented chronically hypoperfused cognitive deficits and brain damage at least partly through an antioxidant effect and improved cholinergic activity and suggest that LISA may have therapeutic potential in treating vascular dementia and cerebrovascular insufficiency.