N
Nadejda Valtcheva
Researcher at University of Tübingen
Publications - 6
Citations - 806
Nadejda Valtcheva is an academic researcher from University of Tübingen. The author has contributed to research in topics: cGMP-dependent protein kinase & Recombinase. The author has an hindex of 5, co-authored 5 publications receiving 748 citations.
Papers
More filters
Journal ArticleDOI
Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells
Kamran Ghoreschi,Jürgen Brück,Christina Kellerer,Caishu Deng,Haiyan Peng,Oliver Rothfuss,Rehana Z. Hussain,Anne R. Gocke,Annedore Respa,Ivana Glocova,Nadejda Valtcheva,Eva Alexander,Susanne Feil,Robert Feil,Klaus Schulze-Osthoff,Rudolf A. Rupec,Amy E. Lovett-Racke,Amy E. Lovett-Racke,Ralf Dringen,Michael K. Racke,Michael K. Racke,Martin Röcken +21 more
TL;DR: Fumarates suppress Th1 responses by blocking IL-12 and IL-23 production by dendritic cells via distinct pathways through distinct pathways.
Book ChapterDOI
Inducible Cre Mice
TL;DR: How tamoxifen-dependent Cre recombinases work and how they can be used to generate time- and tissue-specific mouse mutants are described and the focus will be on the CreER(T2) recombinase, which is currently the most successful CreER version.
Journal ArticleDOI
Rescue of cGMP Kinase I Knockout Mice by Smooth Muscle–Specific Expression of Either Isozyme
Silke Weber,Dominik Bernhard,Robert Lukowski,Pascal Weinmeister,René Wörner,Jörg W. Wegener,Nadejda Valtcheva,Susanne Feil,Jens Schlossmann,Franz Hofmann,Robert Feil +10 more
TL;DR: It is shown that cGKI in smooth muscle is essential and that either c GKI isozyme alone can rescue basic vascular and intestinal smooth muscle functions.
Journal ArticleDOI
The Commonly Used cGMP-dependent Protein Kinase Type I (cGKI) Inhibitor Rp-8-Br-PET-cGMPS Can Activate cGKI in Vitro and in Intact Cells *
Nadejda Valtcheva,Peter Nestorov,Alexander Beck,Michael Russwurm,Matthias Hillenbrand,Pascal Weinmeister,Robert Feil +6 more
TL;DR: In this paper, the authors evaluated the properties of Rp-PET using cGKI-expressing and CGA-deficient primary vascular smooth muscle cells (VSMCs) and an engineered cGMP sensor protein.
The Commonly Used cGMP-dependent Protein Kinase Type I (cGKI) Inhibitor Rp-8-Br-PET-cGMPS Can Activate cGKI in Vitro
Nadejda Valtcheva,Peter Nestorov,Alexander Beck,Michael Russwurm,Matthias Hillenbrand,Pascal Weinmeister,Robert Feil +6 more
TL;DR: Rp-PET is a partial cGKIα agonist that under certain conditions stimulates rather than inhibits c GKI activity in vitro and in intact cells, indicating that cGMP-dependent protein kinase type I has a role in signaling processes.