E
Eva Alexander
Researcher at University of Tübingen
Publications - 5
Citations - 530
Eva Alexander is an academic researcher from University of Tübingen. The author has contributed to research in topics: Promoter & Chromatin immunoprecipitation. The author has an hindex of 5, co-authored 5 publications receiving 501 citations.
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Journal ArticleDOI
Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells
Kamran Ghoreschi,Jürgen Brück,Christina Kellerer,Caishu Deng,Haiyan Peng,Oliver Rothfuss,Rehana Z. Hussain,Anne R. Gocke,Annedore Respa,Ivana Glocova,Nadejda Valtcheva,Eva Alexander,Susanne Feil,Robert Feil,Klaus Schulze-Osthoff,Rudolf A. Rupec,Amy E. Lovett-Racke,Amy E. Lovett-Racke,Ralf Dringen,Michael K. Racke,Michael K. Racke,Martin Röcken +21 more
TL;DR: Fumarates suppress Th1 responses by blocking IL-12 and IL-23 production by dendritic cells via distinct pathways through distinct pathways.
Journal ArticleDOI
IκBζ Is a Transcriptional Key Regulator of CCL2/MCP-1
Dominic G. Hildebrand,Eva Alexander,Sebastian Hörber,Simon Lehle,Kerstin Obermayer,Niels-Arne Münck,Oliver Rothfuss,Julia-Stefanie Frick,Masami Morimatsu,Ingo Schmitz,Johannes Roth,Jan Ehrchen,Frank Essmann,Klaus Schulze-Osthoff,Klaus Schulze-Osthoff +14 more
TL;DR: A distinguished role of IκBζ is suggested in mediating the targeted recruitment of monocytes in response to local inflammatory events by directly recruited to the proximal promoter region of the Ccl2 gene.
Journal ArticleDOI
Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level
Graupner,Eva Alexander,Tim Overkamp,Oliver Rothfuss,De Laurenzi,Bernhard Gillissen,Peter T. Daniel,Klaus Schulze-Osthoff,Frank Essmann +8 more
TL;DR: It is suggested that expression of Bak can be induced by both, p53 and p73 utilizing different binding sites within the bak promoter region, and Interestingly, Bak expression can also beinduced by p73 that binds however to each of the three p53-binding siteswithin the bk promoter region.
Journal ArticleDOI
IκBζ is a regulator of the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescence.
Eva Alexander,Dominic G. Hildebrand,Anna Kriebs,Kerstin Obermayer,Marianne Manz,Oliver Rothfuss,Klaus Schulze-Osthoff,Klaus Schulze-Osthoff,Frank Essmann +8 more
TL;DR: This work proposes an important and hitherto unappreciated role of I&kgr;B&zgr; in SASP formation in both DNA damage- and oncogene-induced senescence.
Journal Article
I kappa B zeta Is a Transcriptional Key Regulator of CCL2/MCP-1
Dominic G. Hildebrand,Eva Alexander,Sebastian Hoerber,Simon Lehle,Kerstin Obermayer,Niels-Arne Muenck,Oliver Rothfuss,Julia-Stefanie Frick,Masami Morimatsu,Ingo Schmitz,Johannes Roth,Jan Ehrchen,Frank Essmann,Klaus Schulze-Osthoff +13 more