H
Hala Girgis
Researcher at Toronto General Hospital
Publications - 4
Citations - 60
Hala Girgis is an academic researcher from Toronto General Hospital. The author has contributed to research in topics: Adenocarcinoma & Genome-wide association study. The author has an hindex of 3, co-authored 4 publications receiving 53 citations. Previous affiliations of Hala Girgis include Princess Margaret Cancer Centre.
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Journal ArticleDOI
Appropriateness of Using Patient-Derived Xenograft Models for Pharmacologic Evaluation of Novel Therapies for Esophageal/Gastro-Esophageal Junction Cancers
Lorin Dodbiba,Jennifer Teichman,Andrew Fleet,Henry Thai,Maud H.W. Starmans,Roya Navab,Zhuo Chen,Hala Girgis,Lawson Eng,Osvaldo Espin-Garcia,Xiaowei Shen,Bizhan Bandarchi,Joerg Schwock,Ming-Sound Tsao,Hala El-Zimaity,Sandy D. Der,Wei Xu,Robert G. Bristow,Gail Darling,Paul C. Boutros,Laurie Ailles,Geoffrey Liu +21 more
TL;DR: Because of their ability to recapitulate primary tumor characteristics during engraftment and across serial passaging, PTXGs can be useful clinical systems for assessment of drug sensitivity of human E/GEJ cancers.
Journal ArticleDOI
Primary esophageal and gastro-esophageal junction cancer xenograft models: clinicopathological features and engraftment
Lorin Dodbiba,Jennifer Teichman,Andrew Fleet,Henry Thai,Bin Sun,Bin Sun,Devang Panchal,Devang Panchal,Devalben Patel,Alvina Tse,Zhuo Chen,Olusola Olusesan Faluyi,Daniel J. Renouf,Hala Girgis,Bizhan Bandarchi,Joerg Schwock,Wei Xu,Robert G. Bristow,Robert G. Bristow,Robert G. Bristow,Ming-Sound Tsao,Ming-Sound Tsao,Gail Darling,Laurie Ailles,Laurie Ailles,Hala El-Zimaity,Geoffrey Liu +26 more
TL;DR: Xenografts maintained similar histology and morphological characteristics with only minor variations even after multiple passaging in most instances.
Journal ArticleDOI
Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma.
Jennifer Teichman,Lorin Dodbiba,Henry Thai,Andrew Fleet,Trevor Morey,Lucy Liu,Lucy Liu,Madison McGregor,Dangxiao Cheng,Zhuo Chen,Gail Darling,Yonathan Brhane,Yuyao Song,Osvaldo Espin-Garcia,Wei Xu,Wei Xu,Hala Girgis,Joerg Schwock,Helen Mackay,Robert G. Bristow,Robert G. Bristow,Laurie Ailles,Laurie Ailles,Geoffrey Liu,Geoffrey Liu +24 more
TL;DR: Hh signaling mediates the radiation response in some EAC PDX models, and inhibition of this pathway may augment the efficacy of radiation in tumours that are Hh dependent.
Journal ArticleDOI
A genome-wide association study of non-HPV-related head and neck squamous cell carcinoma identifies prognostic genetic sequence variants in the MAP-kinase and hormone pathways
Abul Kalam Azad,Isabelle Bairati,Xin Qiu,Hala Girgis,Lu Cheng,Daryl Waggott,Dangxiao Cheng,Maryam Mirshams,James Ho,André Fortin,Eric Vigneault,Shao Hui Huang,Brian O'Sullivan,John Waldron,Paul C. Boutros,Paul C. Boutros,David P. Goldstein,François Meyer,Wei Xu,Geoffrey Liu,Geoffrey Liu,Geoffrey Liu +21 more
TL;DR: Putatively functional polymorphisms in the MAP-Kinase and estrogen pathways, identified through GWAS and replicated in an independent dataset were associated with the survival of HNC patients.