H
Halima Moncrieffe
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 37
Citations - 1662
Halima Moncrieffe is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Arthritis & T cell. The author has an hindex of 16, co-authored 36 publications receiving 1497 citations. Previous affiliations of Halima Moncrieffe include University of Cincinnati Academic Health Center & National Institute for Medical Research.
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Journal ArticleDOI
Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers.
Kiran Nistala,Halima Moncrieffe,Katy Newton,Hemlata Varsani,Patricia Hunter,Lucy R. Wedderburn +5 more
TL;DR: This study is the first to define the frequency and characteristics of “Th17” cells in JIA and suggest that these highly proinflammatory cells contribute to joint pathology, as indicated by relationships with clinical phenotypes, and that the balance between IL-17+ T cells and Treg cells may be critical to outcome.
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CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production.
Thomas Barthlott,Halima Moncrieffe,Marc Veldhoen,Christopher J. Atkins,Jillian R. Christensen,Anne O'Garra,Brigitta Stockinger +6 more
TL;DR: O adoptive transfer into lymphopenic mice showed that CD25+ CD4+ T cells interfere with CD25 up-regulation on co-transferred naive T cells, while increasing their own CD25 levels, providing a link explaining the apparent difference in regulatory mechanisms in vitro and in vivo.
Journal ArticleDOI
Modulation of Dendritic Cell Function by Naive and Regulatory CD4+ T Cells
Marc Veldhoen,Halima Moncrieffe,Richard J. Hocking,Christopher J. Atkins,Brigitta Stockinger +4 more
TL;DR: Mutual interactions between DC and CD4+ T cell subpopulations following contact with pathogens are likely to influence the strength and quality of incipient immune responses in the local microenvironment.
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High Expression of the Ectonucleotidase CD39 on T Cells from the Inflamed Site Identifies Two Distinct Populations, One Regulatory and One Memory T Cell Population
Halima Moncrieffe,Kiran Nistala,Yasmine Kamhieh,Jamie G. Evans,Ayad Eddaoudi,Simon Eaton,Lucy R. Wedderburn +6 more
TL;DR: The data suggest that in human CD4+ T cells from the inflamed site, CD39 can be highly expressed on two populations, one regulatory and the other of a memory phenotype, and a novel population of humanCD4 T cells that express CD39 yet are Foxp3 negative are reported.
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The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis
Dirk Holzinger,Michael Frosch,Astrid Kastrup,Femke H M Prince,Marieke H Otten,Lisette W A van Suijlekom-Smit,Rebecca ten Cate,Esther P A H Hoppenreijs,Sandra Hansmann,Halima Moncrieffe,Simona Ursu,Lucy R. Wedderburn,Johannes Roth,Dirk Foell,Helmut Wittkowski +14 more
TL;DR: MRP8/14 serum concentrations are the first predictive biomarker indicating subclinical disease activity and stratifying patients at risk of relapse during times of clinically inactive disease.