B
Brigitta Stockinger
Researcher at Francis Crick Institute
Publications - 143
Citations - 25195
Brigitta Stockinger is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 62, co-authored 137 publications receiving 22395 citations. Previous affiliations of Brigitta Stockinger include Medical Research Council & Max Planck Society.
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Journal ArticleDOI
TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-Producing T cells
Marc Veldhoen,Richard J. Hocking,Christopher J. Atkins,Richard M. Locksley,Brigitta Stockinger +4 more
TL;DR: The data indicate that, in the presence of IL-6, TGFbeta1 subverts Th1 and Th2 differentiation for the generation ofIL-17-producing T cells.
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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins.
Marc Veldhoen,Keiji Hirota,Astrid M. Westendorf,Jan Buer,Laure Dumoutier,Jean-Christophe Renauld,Brigitta Stockinger +6 more
TL;DR: It is shown that in the CD4+ T-cell lineage of mice AHR expression is restricted to the TH17 cell subset and its ligation results in the production of the TH16 cytokine interleukin (IL)-22, and AHR ligands may represent co-factors in the development of autoimmune diseases.
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Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
Marc Veldhoen,Catherine Uyttenhove,Jacques Van Snick,Helena Helmby,Astrid M. Westendorf,Jan Buer,Bruno Martin,Christoph Wilhelm,Brigitta Stockinger +8 more
TL;DR: It is shown that transforming growth factor-β constitutes a regulatory 'switch' that in combination with other cytokines can 'reprogram' effector T cell differentiation along different pathways.
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Fate mapping of IL-17-producing T cells in inflammatory responses
Keiji Hirota,João H. Duarte,Marc Veldhoen,Marc Veldhoen,Eve Hornsby,Ying Li,Daniel J. Cua,Helena Ahlfors,Christoph Wilhelm,Mauro Tolaini,Ursula Menzel,Anna Garefalaki,Alexandre J. Potocnik,Brigitta Stockinger +13 more
TL;DR: A reporter mouse strain designed to map the fate of cells that have activated interleukin 17A (IL-17A) allows the actual functional fate of effector T cells to be related to TH17 developmental origin regardless of IL-17 expression.
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Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals
TL;DR: In innate receptor expression linked with IL-17 production characterizes TCRgammadelta T cells as an efficient first line of defense that can orchestrate an inflammatory response to pathogen-derived as well as environmental signals long before Th17 cells have sensed bacterial invasion.