Thomas Barthlott

TL;DR: Mouse IL-10-TReg obtained using either in vitro or in vivo regimens of antigenic stimulation did not express the CD4+CD25+ TReg-associated transcription factor Foxp3, and despite the absence of Fox p3 expression, homogeneous populations of IL- 10- TReg inhibited the in vitro proliferation of CD4-CD25− T cells with a similar efficiency to that of CD 4+CD 25+ TRega.

TL;DR: It is proposed that dysregulated expansion of potentially pathogenic T cells in a lymphopenic environment can be prevented by members of the naive T cell repertoire, irrespective of their specificity, as a side effect of their response to homeostatic and antigenic stimulation.

TL;DR: O adoptive transfer into lymphopenic mice showed that CD25+ CD4+ T cells interfere with CD25 up-regulation on co-transferred naive T cells, while increasing their own CD25 levels, providing a link explaining the apparent difference in regulatory mechanisms in vitro and in vivo.

TL;DR: Comparison of survival characteristics of transgenic and polyclonal CD4 and CD8 T cells shows that survival signals are relayed differently in the two lymphocyte subpopulations, excluding a role for this molecule as a key factor in differential survival of CD4 vs CD8T cells.

TL;DR: Alternative mechanisms are involved in controlling the numbers of T cells in the face of ongoing new production from the thymus and continuous expansion in response to antigenic stimuli, and it is understandable that the immune system has developed several layers of homeostatic control mechanisms.