H
Hamish W King
Researcher at Queen Mary University of London
Publications - 36
Citations - 3274
Hamish W King is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Chromatin & Regulation of gene expression. The author has an hindex of 15, co-authored 33 publications receiving 2032 citations. Previous affiliations of Hamish W King include Flinders Medical Centre & Flinders University.
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Journal ArticleDOI
Hypoxic enhancement of exosome release by breast cancer cells
TL;DR: Evidence is provided that hypoxia promotes the release of exosomes by breast cancer cells, and that this hypoxic response may be mediated by HIF-1 α, and this has significant implications for understanding the hypoxic tumour phenotype.
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Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation
Neil P. Blackledge,Anca M. Farcas,Takashi Kondo,Hamish W King,Joanna F. McGouran,Lars L. P. Hanssen,Shinsuke Ito,Sarah Cooper,Kaori Kondo,Yoko Koseki,Tomoyuki Ishikura,Hannah K. Long,Thomas W. Sheahan,Neil Brockdorff,Benedikt M. Kessler,Haruhiko Koseki,Robert J. Klose +16 more
TL;DR: Using a de novo targeting assay in mouse embryonic stem cells, it is found that PRC1-dependent H2AK119ub1 leads to recruitment of PRC2 and H3K27me3 to effectively initiate a polycomb domain, providing a surprising PRC 1-dependent logic forPRC2 occupancy at target sites in vivo.
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Cell2location maps fine-grained cell types in spatial transcriptomics
Vitalii Kleshchevnikov,Artem Shmatko,Emma Dann,Alexander Aivazidis,Hamish W King,Tong Li,Rasa Elmentaite,Artem Lomakin,Veronika R. Kedlian,Adam Gayoso,Mika Sarkin Jain,Jun Sung Park,Lauma Ramona,Elizabeth Tuck,Anna Arutyunyan,Roser Vento-Tormo,Moritz Gerstung,Louisa K. James,Oliver Stegle,Omer Ali Bayraktar +19 more
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The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells
Hamish W King,Robert J. Klose +1 more
TL;DR: It is discovered that the pluripotency-associated pioneer factor OCT4 binds chromatin to shape accessibility, transcription factor co-binding, and regulatory element function in mouse embryonic stem cells.
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Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression
Nadezda A. Fursova,Neil P. Blackledge,Manabu Nakayama,Shinsuke Ito,Yoko Koseki,Anca M. Farcas,Hamish W King,Haruhiko Koseki,Robert J. Klose +8 more
TL;DR: It is demonstrated that canonical Polycomb repressive complex 1 (PRC1), which mediates higher-order chromatin structures, contributes little to gene repression, and a new variant PRC1-dependent logic for Polycomb-mediated gene repression is revealed.