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Isaac M. Chiu
Researcher at Harvard University
Publications - 84
Citations - 8403
Isaac M. Chiu is an academic researcher from Harvard University. The author has contributed to research in topics: Immune system & Nociceptor. The author has an hindex of 36, co-authored 68 publications receiving 6117 citations. Previous affiliations of Isaac M. Chiu include Boston Children's Hospital.
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Bacteria activate sensory neurons that modulate pain and inflammation
Isaac M. Chiu,Balthasar A. Heesters,Balthasar A. Heesters,Nader Ghasemlou,Christian A. von Hehn,Fan Zhao,Johnathan V. Tran,Brian J. Wainger,Amanda Strominger,Sriya Muralidharan,Alexander R. Horswill,Juliane Bubeck Wardenburg,Sun Wook Hwang,Sun Wook Hwang,Michael C. Carroll,Clifford J. Woolf +15 more
TL;DR: It is demonstrated that bacteria directly activate nociceptors, and that the immune response mediated through TLR2, MyD88, T cells, B cells, and neutrophils and monocytes is not necessary for Staphylococcus aureus-induced pain in mice.
Journal ArticleDOI
Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation.
TL;DR: The dialog between nociceptor neurons and the immune system is a fundamental aspect of inflammation, both acute and chronic, and a better understanding of these interactions could produce approaches to treat chronic pain and inflammatory diseases.
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A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model
Isaac M. Chiu,Emiko T.A. Morimoto,Hani Goodarzi,Jennifer T. Liao,Sean O'Keeffe,Hemali Phatnani,Michael Muratet,Michael C. Carroll,Shawn Levy,Saeed Tavazoie,Richard M. Myers,Tom Maniatis +11 more
TL;DR: It is found that SOD1(G93A) microglia are not derived from infiltrating monocytes, and that both potentially neuroprotective and toxic factors, including Alzheimer's disease genes, are concurrently upregulated.
Journal ArticleDOI
Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology
Isaac M. Chiu,Isaac M. Chiu,Christian A. von Hehn,Christian A. von Hehn,Clifford J. Woolf,Clifford J. Woolf +5 more
TL;DR: Understanding the coordinated interaction of peripheral neurons with immune cells may advance therapeutic approaches to increase host defense and suppress immunopathology.
Journal ArticleDOI
The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation
Antonia Wallrapp,Samantha J. Riesenfeld,Patrick R. Burkett,Raja-Elie E. Abdulnour,Jackson Nyman,Danielle Dionne,Matan Hofree,Michael S. Cuoco,Christopher Rodman,Daneyal Farouq,Brian J. Haas,Timothy L. Tickle,John J. Trombetta,Pankaj Baral,Christoph S.N. Klose,Tanel Mahlakõiv,David Artis,Orit Rozenblatt-Rosen,Isaac M. Chiu,Bruce D. Levy,Monika S. Kowalczyk,Aviv Regev,Aviv Regev,Vijay K. Kuchroo,Vijay K. Kuchroo +24 more
TL;DR: In this paper, the authors profiled mouse lung-resident ILCs using single-cell RNA sequencing at steady state and after in vivo stimulation with the alarmin cytokines IL-25 and IL-33.