H
Hani Zaher
Researcher at Pfizer
Publications - 10
Citations - 989
Hani Zaher is an academic researcher from Pfizer. The author has contributed to research in topics: Organic anion-transporting polypeptide & Aryl hydrocarbon receptor. The author has an hindex of 10, co-authored 10 publications receiving 946 citations. Previous affiliations of Hani Zaher include Boehringer Ingelheim & National Institutes of Health.
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Journal ArticleDOI
Protection against Acetaminophen Toxicity in CYP1A2 and CYP2E1 Double-Null Mice ☆
Hani Zaher,Jeroen Buters,Jerrold M. Ward,Mary K. Bruno,Angela M. Lucas,Stephan T. Stern,Steven D. Cohen,Frank J. Gonzalez +7 more
TL;DR: The protection against APAP toxicity afforded by deletion of both CYP2E1 and CYP1A2 likely reflects greatly diminished production of the toxic electrophile, NAPQI.
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The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis.
Hani Zaher,Pedro M. Fernández-Salguero,John J. Letterio,M. Saeed Sheikh,Albert J. Fornace,Anita B. Roberts,Frank J. Gonzalez +6 more
TL;DR: Findings suggest that the phenotypic abnormalities in Ahr-/- mice could be mediated in part by abnormal levels of active TGFbeta and altered cell cycle control.
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Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe.
Bradley L. Urquhart,Joseph A. Ware,Rommel G. Tirona,Richard H. Ho,Brenda F. Leake,Ute I. Schwarz,Hani Zaher,Joe Palandra,Jamie Gregor,George K. Dresser,Richard B. Kim +10 more
TL;DR: Sulfasalazine may prove to have utility as in vivo probe for assessing the clinical impact of BCRP for the disposition and efficacy of drugs and links commonly occurring SNPs in BCRp with significantly increased oral sulfasalazines plasma exposure in humans.
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Curcumin Inhibits the Activity of ABCG2/BCRP1, a Multidrug Resistance-Linked ABC Drug Transporter in Mice
Suneet Shukla,Hani Zaher,Hani Zaher,Anika M.S. Hartz,Björn Bauer,Joseph A. Ware,Joseph A. Ware,Suresh V. Ambudkar +7 more
TL;DR: This study provides the first in vivo evidence for the inhibition by curcumin of ABCG2-mediated efflux of sulfasalazine in mice and proposes that non-toxic concentrations ofCurcumin may be used to enhance drug exposure when the rate-limiting step of drug absorption and/or tissue distribution is impacted by ABCG 2.
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Targeted Disruption of Murine Organic Anion-Transporting Polypeptide 1b2 (oatp1b2/ Slco1b2) Significantly Alters Disposition of Prototypical Drug Substrates Pravastatin and Rifampin
Hani Zaher,Henriette E. Meyer zu Schwabedissen,Rommel G. Tirona,Melissa L. Cox,Leslie A. Obert,Nidhi Agrawal,Joe Palandra,Jeffrey L. Stock,Richard B. Kim,Joseph A. Ware +9 more
TL;DR: The first report of altered drug disposition profile in the Slco1b2 knockout mice is reported and suggests the utility of this model for understanding the in vivo role of hepatic OATP transporters in drug disposition.