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Albert J. Fornace
Researcher at Georgetown University
Publications - 418
Citations - 42920
Albert J. Fornace is an academic researcher from Georgetown University. The author has contributed to research in topics: DNA damage & DNA repair. The author has an hindex of 106, co-authored 403 publications receiving 40889 citations. Previous affiliations of Albert J. Fornace include King Abdulaziz University & National Institutes of Health.
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Journal ArticleDOI
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
Michael B. Kastan,Qimin Zhan,Wafik S. El-Deiry,Tyler Jacks,William V. Walsh,Beverly Plunkett,Bert Vogelstein,Albert J. Fornace +7 more
TL;DR: Three participants are identified (AT gene(s), p53, and GADD45) in a signal transduction pathway that controls cell cycle arrest following DNA damage; abnormalities in this pathway probably contribute to tumor development.
Journal ArticleDOI
An Information-Intensive Approach to the Molecular Pharmacology of Cancer
John N. Weinstein,Timothy G. Myers,Patrick M. O'Connor,Stephen H. Friend,Albert J. Fornace,Kurt W. Kohn,Tito Fojo,Susan E. Bates,Larry Rubinstein,N. Leigh Anderson,John K. Buolamwini,William W. van Osdol,Anne Monks,Dominic A. Scudiero,Edward A. Sausville,Daniel W. Zaharevitz,Barry Bunow,Vellarkad N. Viswanadhan,George S. Johnson,Robert Wittes,Kenneth D. Paull +20 more
TL;DR: Information is being used to search for candidate anticancer drugs that are not dependent on intact p53 suppressor gene function for their activity, and it remains to be seen how effective this information-intensive strategy will be at generating new clinically active agents.
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Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
Martin Smith,I-Tsuen Chen,Qimin Zhan,Insoo Bae,Catheryne Chen,Tona M. Gilmer,Michael B. Kastan,Patrick M. O'Connor,Albert J. Fornace +8 more
TL;DR: Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair, establishing GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.
Journal Article
Characterization of the p53 Tumor Suppressor Pathway in Cell Lines of the National Cancer Institute Anticancer Drug Screen and Correlations with the Growth-Inhibitory Potency of 123 Anticancer Agents
Patrick M. O'Connor,Joany Jackman,Insoo Bae,Timothy G. Myers,Saijun Fan,Masato Mutoh,Dominic A. Scudiero,Ann Monks,Edward A. Sausville,John N. Weinstein,Stephen H. Friend,Albert J. Fornace,Kurt W. Kohn +12 more
TL;DR: The analysis revealed that cells with mutant p53 sequence tended to exhibit less growth inhibition in this screen than the wild-type p53 cell lines when treated with the majority of clinically used anticancer agents: including DNA cross-linking agents, antimetabolites, and topoisomerase I and II inhibitors.
Journal ArticleDOI
DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein
Hien Tran,Anne Brunet,Jill M. Grenier,Sandeep Robert Datta,Albert J. Fornace,Peter S. DiStefano,Lillian W. Chiang,Michael E. Greenberg +7 more
TL;DR: Findings indicate that in mammals FOXO3a regulates the resistance of cells to stress by inducing DNA repair and thereby may also affect organismal life-span.