Hanneke N. Monsuur

TL;DR: Endocytosis and recycling play an important role in the regulation of integrin turnover and integrin redistribution in adherent cells, especially during dynamic processes such as cell migration and invasion.

TL;DR: Analyzing 20 breast cancer-related genes in 104 invasive breast cancers with the use of multiplex ligation-dependent probe amplification allowed to simultaneously assess copy numbers of 20 important breast cancer genes, providing an overview of the most frequent (co)amplifications as well as interesting phenotypic correlations, and thereby data on the potential importance of these genes in breast cancer.

TL;DR: The data demonstrate that single mutations in sf3b1 are associated with increased DNA damage and/or an aberrant response to DNA damage, and may offer an explanation for the poor prognosis associated with SF3B1 mutations.

TL;DR: Highgrade DCIS showed more copy number changes than low/intermediate grade DCIS with specifically involved genes, supporting a model in which different histological grades of DCIS are associated with distinct genomic changes that progress to IDC in different routes.

TL;DR: These skin models provide a platform for testing the mode of action of novel compounds for enhanced and scar free wound healing and also to study migration and distribution of fibroblasts into the dermis.