H
Hannie Douben
Researcher at Erasmus University Rotterdam
Publications - 33
Citations - 913
Hannie Douben is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Comparative genomic hybridization & Biology. The author has an hindex of 17, co-authored 29 publications receiving 787 citations. Previous affiliations of Hannie Douben include Erasmus University Medical Center.
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Journal ArticleDOI
Congenital Diaphragmatic Hernia and Chromosome 15q26: Determination of a Candidate Region by Use of Fluorescent In Situ Hybridization and Array-Based Comparative Genomic Hybridization
M. Klaassens,M. F. van Dooren,H.J. Eussen,Hannie Douben,A.T. den Dekker,Charles Lee,Patricia K. Donahoe,Robert Jan H. Galjaard,Natascha N T Goemaere,R.R. de Krijger,Carine Wouters,Joost Wauters,Ben A. Oostra,Dick Tibboel,A. de Klein +14 more
TL;DR: This study focused on the most frequent structural anomaly found: a deletion on chromosome 15q, which contains four known genes, of which two--NR2F2 and CHD2--are particularly intriguing gene candidates for CDH.
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Aging of bone marrow– and umbilical cord–derived mesenchymal stromal cells during expansion
Samantha F.H. de Witte,Eleonora E. Lambert,Ana Merino,Tanja Strini,Hannie Douben,Lisa O'Flynn,Steve J. Elliman,Annelies de Klein,Philip N. Newsome,Carla C. Baan,Martin J. Hoogduijn +10 more
TL;DR: After long-term in vitro expansion, phenotype of bmMSCs and ucMSCs remains stable and cells exhibit similar immunogenic properties compared with lower passage cells, however, immunosuppressive properties of MSCs are reduced.
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Mesenchymal stem cells derived from adipose tissue are not affected by renal disease
Marieke Roemeling-van Rhijn,Marlies E.J. Reinders,Annelies de Klein,Hannie Douben,Sander S. Korevaar,F. Mensah,Frank J. M. F. Dor,Jan N. M. IJzermans,Michiel G. H. Betjes,Carla C. Baan,Willem Weimar,Martin J. Hoogduijn +11 more
TL;DR: The results indicate the feasibility of mesenchymal stem cells use in autologous cell therapy in patients with renal disease, as they have similar characteristics and functionality as those from healthy controls.
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Early-onset parkinsonism caused by alpha-synuclein gene triplication: Clinical and genetic findings in a novel family.
Simone Olgiati,Astrid Thomas,Marialuisa Quadri,Guido J. Breedveld,Josja Graafland,H.J. Eussen,Hannie Douben,Annelies de Klein,Marco Onofrj,Vincenzo Bonifati +9 more
TL;DR: The data reinforce the view that SNCA triplications cause early-onset parkinsonism, with prominent non-motor features.
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Epigenetic characterization of the FMR1 promoter in induced pluripotent stem cells from human fibroblasts carrying an unmethylated full mutation
Celine de Esch,Mehrnaz Ghazvini,Friedemann Loos,Nune Schelling-Kazaryan,W. Widagdo,Shashini T. Munshi,Erik van der Wal,Hannie Douben,Nilhan Gunhanlar,Steven A. Kushner,W.W.M. Pim Pijnappel,Femke M.S. de Vrij,Niels Geijsen,Joost Gribnau,Rob Willemsen +14 more
TL;DR: It is demonstrated that the standard reprogramming procedure leads to epigenetic silencing of the fully mutated FMR1 gene.