Joost Gribnau

TL;DR: In addition to uncovering a new principle of cis-regulatory architecture of mammalian chromosomes, this study sets the stage for the full genetic dissection of the mouse X-inactivation centre.

TL;DR: Large transcripts precisely delineate the active domains at key cell cycle points associated with chromatin transitions and remodeling, suggesting that intergenic transcription is required for chromatin remodeling of chromosomal domains.

TL;DR: It is found that loci on the active X form multiple long-range interactions, with spatial segregation of active and inactive chromatin, and a role for Xist RNA in shaping the conformation of the inactive X chromosome at least partially independent of transcription.

TL;DR: It is demonstrated that human iPSC reprogramming in the presence of LIF yields human stem cells that display morphological, molecular, and functional properties of murine ESCs and the hLR5 state facilitates gene targeting, and provides a powerful tool for the generation of recombinant human pluripotent stem cell lines.

TL;DR: It is shown that EKLF knockout mice express the human epsilon and gamma-globin genes normally in embryonic red cells, and this findings provide further evidence that developmental modulation of globin gene expression within individual cells is accomplished by altering the frequency and/or duration of transcriptional periods of a gene rather than changing the rate of transcription.