J
Jan N. M. IJzermans
Researcher at Erasmus University Rotterdam
Publications - 579
Citations - 22286
Jan N. M. IJzermans is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Transplantation & Kidney transplantation. The author has an hindex of 62, co-authored 536 publications receiving 18157 citations. Previous affiliations of Jan N. M. IJzermans include Erasmus University Medical Center.
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Journal ArticleDOI
A Comparison of Suture Repair with Mesh Repair for Incisional Hernia
R W Luijendijk,Wim C. J. Hop,van den Tol Mp,de Lange Dc,Braaksma Mm,Jan N. M. IJzermans,Boelhouwer Ru,de Vries Bc,Salu Mk,Wereldsma Jc,Bruijninckx Cm,J. Jeekel +11 more
TL;DR: Among patients with midline abdominal incisional hernias, mesh repair is superior to suture repair with regard to the recurrence of hernia, regardless of the size of the hernia.
Journal ArticleDOI
Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver
Meritxell Huch,Helmuth Gehart,Ruben van Boxtel,Karien Hamer,Francis Blokzijl,Monique M A Verstegen,Ewa Ellis,Martien van Wenum,Sabine A. Fuchs,Joep de Ligt,Marc van de Wetering,Nobuo Sasaki,Susanne J. Boers,Hans Kemperman,Jeroen de Jonge,Jan N. M. IJzermans,Edward E. S. Nieuwenhuis,Ruurdtje Hoekstra,Stephen C. Strom,Robert R G Vries,Luc J. W. van der Laan,Edwin Cuppen,Hans Clevers +22 more
TL;DR: Conditions allowing long-term expansion of adult bile duct-derived bipotent progenitor cells from human liver opens up experimental avenues for disease modeling, toxicology studies, regenerative medicine, and gene therapy.
Journal ArticleDOI
Human primary liver cancer–derived organoid cultures for disease modeling and drug screening
Laura Broutier,Gianmarco Mastrogiovanni,Monique M A Verstegen,Hayley E. Francies,Lena Morrill Gavarró,Charles R. Bradshaw,George E. Allen,Robert Arnes-Benito,Olga Sidorova,Marcia P. Gaspersz,Nikitas Georgakopoulos,Bon-Kyoung Koo,Sabine Dietmann,Susan E. Davies,Raaj K. Praseedom,Ruby Lieshout,Jan N. M. IJzermans,Stephen J. Wigmore,Kourosh Saeb-Parsy,Mathew J. Garnett,Luc J. W. van der Laan,Meritxell Huch +21 more
TL;DR: The wide-ranging biomedical utilities of PLC-derived organoid models in furthering the understanding of liver cancer biology and in developing personalized-medicine approaches for the disease are demonstrated.
Journal ArticleDOI
Tissue-specific mutation accumulation in human adult stem cells during life
Francis Blokzijl,Joep de Ligt,Myrthe Jager,Valentina Sasselli,Sophie Roerink,Nobuo Sasaki,Meritxell Huch,Sander Boymans,Ewart W. Kuijk,Pjotr Prins,Isaac J. Nijman,Inigo Martincorena,Michal Mokry,Caroline L. Wiegerinck,Sabine Middendorp,Toshiro Sato,Gerald Schwank,Edward E. S. Nieuwenhuis,Monique M A Verstegen,Luc J. W. van der Laan,Jeroen de Jonge,Jan N. M. IJzermans,Robert G.J. Vries,Marc van de Wetering,Michael R. Stratton,Hans Clevers,Edwin Cuppen,Ruben van Boxtel +27 more
TL;DR: This work determines genome-wide mutation patterns in ASCs of the small intestine, colon and liver of human donors with ages ranging from 3 to 87 years by sequencing clonal organoid cultures derived from primary multipotent cells.
Journal ArticleDOI
Stereotactic body radiation therapy for primary and metastatic liver tumors: A single institution phase i-ii study
Alejandra Méndez Romero,Wouter Wunderink,Shahid M. Hussain,Jacco de Pooter,Ben J.M. Heijmen,P. Nowak,Joost J. Nuyttens,Rene P. Brandwijk,Cees Verhoef,Jan N. M. IJzermans,Peter C. Levendag +10 more
TL;DR: SBRT was feasible, with acceptable toxicity and encouraging local control, and Optimal dose-fractionation schemes for HCC with cirrhosis have to be found.