H
Hans-Henrik Fuxelius
Researcher at Uppsala University
Publications - 7
Citations - 888
Hans-Henrik Fuxelius is an academic researcher from Uppsala University. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 4, co-authored 7 publications receiving 849 citations.
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Journal ArticleDOI
The complete genome sequence of Francisella tularensis, the causative agent of tularemia.
Pär Larsson,Petra C. F. Oyston,Patrick S. G. Chain,May C. Chu,Melanie Duffield,Hans-Henrik Fuxelius,Emilio Garcia,Greger Hälltorp,Daniel Johansson,Karen E. Isherwood,Peter D. Karp,Eva Larsson,Ying Liu,Stephen L. Michell,Joann L. Prior,Richard G. Prior,Stephanie Malfatti,Anders Sjöstedt,Kerstin Svensson,Nicholas R Thompson,Lisa M. Vergez,Jonathan Wagg,Brendan W. Wren,Luther E. Lindler,Siv G. E. Andersson,Mats Forsman,Richard W. Titball,Richard W. Titball +27 more
TL;DR: The complete genome sequence of a highly virulent isolate of F. tularensis is reported and an unexpectedly high proportion of disrupted pathways are found, explaining the fastidious nutritional requirements of the bacterium.
Journal ArticleDOI
The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host–cell interaction genes
Nam Hyuk Cho,Hang Rae Kim,Junghee Lee,Seyoon Kim,Jaejong Kim,Sunho Cha,Sang-Yoon Kim,Alistair C. Darby,Hans-Henrik Fuxelius,Jun Yin,Ju Han Kim,Jihun Kim,Sang Joo Lee,Young Sang Koh,Won-Jong Jang,Kyung-Hee Park,Siv G. E. Andersson,Myung-Sik Choi,Ik-Sang Kim +18 more
TL;DR: The results suggest intragenomic duplications or multiple integrations of a massively proliferating conjugative transfer system may drive rare genome variants to fixation, thereby short-circuiting selection for low complexity in bacterial genomes.
Journal ArticleDOI
High-Resolution Genotyping of Chlamydia trachomatis Strains by Multilocus Sequence Analysis
Markus Klint,Hans-Henrik Fuxelius,Renée Röstlinger Goldkuhl,Hanna Skarin,Christian Rutemark,Siv G. E. Andersson,Kenneth Persson,Björn Herrmann +7 more
TL;DR: The MLST system can be used to discriminate C. trachomatis strains and can be applied to high-resolution molecular epidemiology, especially for analysis of the spread of chlamydial infections in the community.
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The genomic and metabolic diversity of Rickettsia
TL;DR: Comparative genomics of Rickettsia and Orientia has revealed an exciting interplay between reductive evolutionary forces acting on metabolic genes in all species and proliferation of mobile genetic elements in some species.
Journal ArticleDOI
The Journey to smORFland
TL;DR: The suggestion that some orphan genes may represent pseudogenes or short fragments of genes that were functional in the genome of a common ancestor, in which the acquired sequences have entered the fragmentation process and thereby lost their similarity to genes in other species.