M
Melanie Duffield
Researcher at Defence Science and Technology Laboratory
Publications - 13
Citations - 1035
Melanie Duffield is an academic researcher from Defence Science and Technology Laboratory. The author has contributed to research in topics: Yersinia pseudotuberculosis & Antigen. The author has an hindex of 10, co-authored 13 publications receiving 990 citations. Previous affiliations of Melanie Duffield include Centers for Disease Control and Prevention & Salisbury University.
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Journal ArticleDOI
The complete genome sequence of Francisella tularensis, the causative agent of tularemia.
Pär Larsson,Petra C. F. Oyston,Patrick S. G. Chain,May C. Chu,Melanie Duffield,Hans-Henrik Fuxelius,Emilio Garcia,Greger Hälltorp,Daniel Johansson,Karen E. Isherwood,Peter D. Karp,Eva Larsson,Ying Liu,Stephen L. Michell,Joann L. Prior,Richard G. Prior,Stephanie Malfatti,Anders Sjöstedt,Kerstin Svensson,Nicholas R Thompson,Lisa M. Vergez,Jonathan Wagg,Brendan W. Wren,Luther E. Lindler,Siv G. E. Andersson,Mats Forsman,Richard W. Titball,Richard W. Titball +27 more
TL;DR: The complete genome sequence of a highly virulent isolate of F. tularensis is reported and an unexpectedly high proportion of disrupted pathways are found, explaining the fastidious nutritional requirements of the bacterium.
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A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens.
Philip L. Felgner,Matthew A. Kayala,Adam Vigil,Chad Burk,Rie Nakajima-Sasaki,Jozelyn Pablo,Douglas M. Molina,Siddiqua Hirst,Janet S. W. Chew,Dongling Wang,Gladys Tan,Melanie Duffield,Ron Yang,Julien Neel,Narisara Chantratita,Greg Bancroft,Ganjana Lertmemongkolchai,D. Huw Davies,Pierre Baldi,Sharon J. Peacock,Richard W. Titball +20 more
TL;DR: Results show that microarrays allow a more comprehensive analysis of the immune response on an antigen- specific, patient-specific, and population-specific basis, can identify serodiagnostic antigens, and contribute to a more detailed understanding of immunogenicity to this pathogen.
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Galleria mellonella as an alternative infection model for Yersinia pseudotuberculosis.
Olivia L. Champion,Ian A. Cooper,Sarah L. James,Donna C. Ford,Andrey V. Karlyshev,Brendan W. Wren,Melanie Duffield,Petra C. F. Oyston,Richard W. Titball +8 more
TL;DR: It is reported that larvae of the wax moth (Galleria mellonella) are susceptible to infection with the human enteropathogen Yersinia pseudotuberculosis at 37 degrees C, and a superoxide dismutase C (sodC) mutant was constructed and tested, showing increased susceptibility to superoxide, a key mechanism of killing in insect haemocytes and mammalian phagocytes.
Journal ArticleDOI
From protein microarrays to diagnostic antigen discovery
Suman Sundaresh,Arlo Randall,Berkay Unal,Jeannine M. Petersen,John T. Belisle,M. Gill Hartley,Melanie Duffield,Richard W. Titball,D. Huw Davies,Philip L. Felgner,Pierre Baldi +10 more
TL;DR: Results strongly indicate that the top-ranked antigens can be considered high-priority candidates for diagnostic development, and have direct relevance to rapid, broad-based diagnostic and vaccine development.
Journal ArticleDOI
Predicting conserved essential genes in bacteria: in silico identification of putative drug targets.
Melanie Duffield,Ian A. Cooper,Erin V. McAlister,Marc Bayliss,Donna C. Ford,Petra C. F. Oyston +5 more
TL;DR: A modified down-selection tool is developed to identify essential genes conserved across diverse genera, which can then be used to facilitate the selection of effective targets for novel broad-spectrum antibiotics.