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Brendan W. Wren
Researcher at University of London
Publications - 386
Citations - 24710
Brendan W. Wren is an academic researcher from University of London. The author has contributed to research in topics: Campylobacter jejuni & Gene. The author has an hindex of 75, co-authored 374 publications receiving 22717 citations. Previous affiliations of Brendan W. Wren include Norwich University & Imperial College London.
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Journal ArticleDOI
The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences
Julian Parkhill,Brendan W. Wren,Karen Mungall,Julian M. Ketley,Carol Churcher,D. Basham,Tracey Chillingworth,Robert L. Davies,Theresa Feltwell,S. Holroyd,Kay Jagels,Andrey V. Karlyshev,Sharon Moule,Mark J. Pallen,Charles W. Penn,Michael A. Quail,Marie-Adèle Rajandream,Kim Rutherford,A. H. M. van Vliet,Sally Whitehead,Bart Barrell +20 more
TL;DR: The genome sequence of C. jejuni NCTC11168 is reported, finding short homopolymeric runs of nucleotides were commonly found in genes encoding the biosynthesis or modification of surface structures, or in closely linked genes of unknown function.
Journal ArticleDOI
Genome sequence of Yersinia pestis , the causative agent of plague
Julian Parkhill,Brendan W. Wren,Nicholas R. Thomson,Richard W. Titball,Matthew T. G. Holden,Michael B. Prentice,Mohammed Sebaihia,Keith D. James,Carol Churcher,Karen Mungall,Stephen Baker,D. Basham,Stephen D. Bentley,Karen Brooks,Ana Cerdeño-Tárraga,Tracey Chillingworth,A. Cronin,Robert L. Davies,P. Davis,Gordon Dougan,Theresa Feltwell,N. Hamlin,S. Holroyd,Kay Jagels,Andrey V. Karlyshev,S. Leather,Sharon Moule,P. C. F. Oyston,Michael A. Quail,Kim Rutherford,Mark Simmonds,Jason Skelton,K. Stevens,Sally Whitehead,Bart Barrell +34 more
TL;DR: The evidence of ongoing genome fluidity, expansion and decay suggests Y. pestis is a pathogen that has undergone large-scale genetic flux and provides a unique insight into the ways in which new and highly virulent pathogens evolve.
Journal ArticleDOI
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
Mohammed Sebaihia,Brendan W. Wren,Peter Mullany,Neil F. Fairweather,Nigel P. Minton,Richard A. Stabler,Nicholas R. Thomson,Adam P. Roberts,Ana Cerdeño-Tárraga,Hongmei Wang,Matthew T. G. Holden,Anne Wright,Carol Churcher,Michael A. Quail,Stephen Baker,Nathalie Bason,Karen Brooks,Tracey Chillingworth,Ann Cronin,Paul Davis,Linda Dowd,Audrey Fraser,Theresa Feltwell,Zahra Hance,S. Holroyd,Kay Jagels,Sharon Moule,Karen Mungall,Claire Price,Ester Rabbinowitsch,Sarah Sharp,Mark Simmonds,K. Stevens,Louise Unwin,Sally Whithead,Bruno Dupuy,Gordon Dougan,Bart Barrell,Julian Parkhill +38 more
TL;DR: The complete genome sequence of Clostridium difficile strain 630, a virulent and multidrug-resistant strain, is determined; it indicates that a large proportion (11%) of the genome consists of mobile genetic elements, mainly in the form of conjugative transposons.
Journal ArticleDOI
N-Linked Glycosylation in Campylobacter jejuni and Its Functional Transfer into E. coli
Michael Wacker,Dennis Linton,Paul G. Hitchen,Mihai Nita-Lazar,Stuart M. Haslam,Simon J. North,Maria Panico,Howard R. Morris,Anne Dell,Brendan W. Wren,Markus Aebi +10 more
TL;DR: It is demonstrated that a functional N-linked glycosylation pathway could be transferred into Escherichia coli and opened up the possibility of engineering permutations of recombinant glycan structures for research and industrial applications.
Journal ArticleDOI
Emergence and global spread of epidemic healthcare-associated Clostridium difficile.
Miao He,Fabio Miyajima,Paul Roberts,Louise Ellison,Derek Pickard,Melissa J. Martin,Thomas R. Connor,Simon R. Harris,Derek Fairley,Kathleen B. Bamford,Kathleen B. Bamford,Stephanie d’Arc,Stephanie d’Arc,Jon S. Brazier,Derek J. Brown,J. E. Coia,Gill Douce,Dale N. Gerding,Heejung Kim,Tse Hsien Koh,Haru Kato,Mitsutoshi Senoh,Tom Louie,Stephen L. Michell,Emma Butt,Sharon J. Peacock,Nicholas M. Brown,Nicholas M. Brown,Thomas V. Riley,Glen Songer,Mark H. Wilcox,Munir Pirmohamed,Ed J. Kuijper,Peter M. Hawkey,Brendan W. Wren,Gordon Dougan,Julian Parkhill,Trevor D. Lawley +37 more
TL;DR: This analysis identifies key genetic changes linked to the rapid transcontinental dissemination of epidemic C. difficile 027/BI/NAP1 and highlights the routes by which it spreads through the global healthcare system.