M
May C. Chu
Researcher at Centers for Disease Control and Prevention
Publications - 21
Citations - 1920
May C. Chu is an academic researcher from Centers for Disease Control and Prevention. The author has contributed to research in topics: Francisella tularensis & Yersinia pestis. The author has an hindex of 17, co-authored 21 publications receiving 1829 citations.
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Journal ArticleDOI
The complete genome sequence of Francisella tularensis, the causative agent of tularemia.
Pär Larsson,Petra C. F. Oyston,Patrick S. G. Chain,May C. Chu,Melanie Duffield,Hans-Henrik Fuxelius,Emilio Garcia,Greger Hälltorp,Daniel Johansson,Karen E. Isherwood,Peter D. Karp,Eva Larsson,Ying Liu,Stephen L. Michell,Joann L. Prior,Richard G. Prior,Stephanie Malfatti,Anders Sjöstedt,Kerstin Svensson,Nicholas R Thompson,Lisa M. Vergez,Jonathan Wagg,Brendan W. Wren,Luther E. Lindler,Siv G. E. Andersson,Mats Forsman,Richard W. Titball,Richard W. Titball +27 more
TL;DR: The complete genome sequence of a highly virulent isolate of F. tularensis is reported and an unexpectedly high proportion of disrupted pathways are found, explaining the fastidious nutritional requirements of the bacterium.
Journal ArticleDOI
Development of a multitarget real-time TaqMan PCR assay for enhanced detection of Francisella tularensis in complex specimens.
TL;DR: The sensitive and specific nature of this rapid multitarget TaqMan assay provides a valuable new tool that with future evaluations can be used for analyzing clinical specimens, field samples during bioterrorism threat assessment, and samples from outbreaks and for improving the understanding of the ecology and environmental prevalence of F. tularensis.
Journal ArticleDOI
New approaches to diagnosis and therapy of tularemia.
Arne Tärnvik,May C. Chu +1 more
TL;DR: The clinical handling of tularemia is currently facilitated by new achievements in molecular diagnostics and, at least with regard to type B Tularemia, by the introduction of quinolones for therapy.
Journal ArticleDOI
Complete Genome Sequence of Yersinia pestis Strains Antiqua and Nepal516: Evidence of Gene Reduction in an Emerging Pathogen
Patrick S. G. Chain,Patrick S. G. Chain,Ping Hu,Stephanie Malfatti,Stephanie Malfatti,Lyndsay Radnedge,Frank W. Larimer,Frank W. Larimer,Lisa M. Vergez,Lisa M. Vergez,Patricia L. Worsham,May C. Chu,Gary L. Andersen +12 more
TL;DR: In this paper, the genomes of two isolates of the "classical" antiqua biovar, strains Antiqua and Nepal516, were compared with the corresponding features in Yersinia pseudotuberculosis, and the results showed that grouping Y. pestis strains based strictly on the classical definition of biovars does not accurately reflect the phylogenetic relationships within this species.
Journal Article
Complete Genome Sequence of Yersinia pestis Strains Antiqua and Nepal516: Evidence of Gene Reduction in an Emerging Pathogen
Patrick S. G. Chain,Ping Hu,Stephanie Malfatti,Lyndsay Radnedge,Frank W. Larimer,Lisa M. Vergez,Patricia L. Worsham,May C. Chu,Gary L. Andersen +8 more
TL;DR: The results presented here clearly demonstrate the differences between the two biovar antiqua lineages and support the notion that grouping Y. pestis strains based strictly on the classical definition of biovars does not accurately reflect the phylogenetic relationships within this species.