H
Hao Zhu
Researcher at University of Texas Southwestern Medical Center
Publications - 102
Citations - 9360
Hao Zhu is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 35, co-authored 81 publications receiving 7734 citations. Previous affiliations of Hao Zhu include Howard Hughes Medical Institute & Boston Children's Hospital.
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Journal ArticleDOI
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
Ryan D. Morin,Nathalie A. Johnson,Tesa M. Severson,Andrew J. Mungall,Jianghong An,Rodrigo Goya,Paul Je,Merrill Boyle,Bruce Woolcock,Florian Kuchenbauer,Damian Yap,Humphries Rk,Obi L. Griffith,Sohrab P. Shah,Hao Zhu,Kimbara M,Shashkin P,Charlot Jf,Tcherpakov M,Richard Corbett,Angela K Y Tam,Richard Varhol,Duane E Smailus,Michelle Moksa,Yongjun Zhao,Allen Delaney,Hong Qian,Inanc Birol,Jacquie Schein,Richard A. Moore,Robert A. Holt,Douglas E. Horsman,Joseph M. Connors,Joseph M. Connors,Steven J.M. Jones,Samuel Aparicio,Martin Hirst,Randy D. Gascoyne,Marco A. Marra,Marco A. Marra +39 more
TL;DR: Recurrent somatic mutations affecting the polycomb-group oncogene EZH2, which encodes a histone methyltransferase responsible for trimethylating Lys27 of histone H3 (H3K27), are reported, consistent with the notion that EZh2 proteins with mutant Tyr641 have reduced enzymatic activity in vitro.
Journal ArticleDOI
The Lin28/let-7 axis regulates glucose metabolism
Hao Zhu,Ng Shyh-Chang,Ayellet V. Segrè,Ayellet V. Segrè,Gen Shinoda,Samar P. Shah,William S. Einhorn,William S. Einhorn,Ayumu Takeuchi,Jesse M. Engreitz,John P. Hagan,Michael G. Kharas,Michael G. Kharas,Achia Urbach,James E. Thornton,Robinson Triboulet,Richard I. Gregory,David Altshuler,David Altshuler,George Q. Daley +19 more
TL;DR: In this paper, the Lin28/let-7 pathway was shown to be a central regulator of mammalian glucose metabolism, including insulin-PI3K-mTOR and IRS2.
The Lin28/let-7 Axis Regulates Glucose Metabolism
Hao Zhu,Ng Shyh-Chang,Ayellet V. Segrè,Ayellet V. Segrè,Gen Shinoda,Samar P. Shah,William S. Einhorn,William S. Einhorn,Ayumu Takeuchi,Jesse M. Engreitz,John P. Hagan,Michael G. Kharas,Michael G. Kharas,Achia Urbach,James E. Thornton,Robinson Triboulet,Richard I. Gregory,David Altshuler,David Altshuler,George Q. Daley +19 more
TL;DR: The Lin28/let-7 pathway is established as a central regulator of mammalian glucose metabolism and enriched for genes containing SNPs associated with type 2 diabetes and control of fasting glucose in human genome-wide association studies.
Journal ArticleDOI
Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation
Ng Shyh-Chang,Jason W. Locasale,Jason W. Locasale,Costas A. Lyssiotis,Costas A. Lyssiotis,Yuxiang Zheng,Ren Yi Teo,Sutheera Ratanasirintrawoot,Jin Zhang,Tamer T. Onder,Juli Unternaehrer,Hao Zhu,John M. Asara,George Q. Daley,George Q. Daley,Lewis C. Cantley +15 more
TL;DR: Threonine and S-adenosylmethionine metabolism are coupled in pluripotent stem cells, resulting in regulation of histone methylation, providing a possible mechanism by which modulation of a metabolic pathway might influence stem cell fate.
Journal ArticleDOI
Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA.
Jason B. Miller,Shuyuan Zhang,Petra Kos,Hu Xiong,Kejin Zhou,Sofya S. Perelman,Hao Zhu,Daniel J. Siegwart +7 more
TL;DR: It is shown that ZNP delivery of sgRNA enables permanent DNA editing with an indefinitely sustained 95 % decrease in protein expression, and represents a promising step towards improving the safety and utility of gene editing.