J
James E. Thornton
Researcher at Boston Children's Hospital
Publications - 13
Citations - 3948
James E. Thornton is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: microRNA & Insulin receptor. The author has an hindex of 11, co-authored 13 publications receiving 3413 citations. Previous affiliations of James E. Thornton include Harvard University.
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The Lin28/let-7 axis regulates glucose metabolism
Hao Zhu,Ng Shyh-Chang,Ayellet V. Segrè,Ayellet V. Segrè,Gen Shinoda,Samar P. Shah,William S. Einhorn,William S. Einhorn,Ayumu Takeuchi,Jesse M. Engreitz,John P. Hagan,Michael G. Kharas,Michael G. Kharas,Achia Urbach,James E. Thornton,Robinson Triboulet,Richard I. Gregory,David Altshuler,David Altshuler,George Q. Daley +19 more
TL;DR: In this paper, the Lin28/let-7 pathway was shown to be a central regulator of mammalian glucose metabolism, including insulin-PI3K-mTOR and IRS2.
The Lin28/let-7 Axis Regulates Glucose Metabolism
Hao Zhu,Ng Shyh-Chang,Ayellet V. Segrè,Ayellet V. Segrè,Gen Shinoda,Samar P. Shah,William S. Einhorn,William S. Einhorn,Ayumu Takeuchi,Jesse M. Engreitz,John P. Hagan,Michael G. Kharas,Michael G. Kharas,Achia Urbach,James E. Thornton,Robinson Triboulet,Richard I. Gregory,David Altshuler,David Altshuler,George Q. Daley +19 more
TL;DR: The Lin28/let-7 pathway is established as a central regulator of mammalian glucose metabolism and enriched for genes containing SNPs associated with type 2 diabetes and control of fasting glucose in human genome-wide association studies.
Journal ArticleDOI
EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent
Kexin Xu,Zhenhua Jeremy Wu,Anna C. Groner,Housheng Hansen He,Changmeng Cai,Rosina T. Lis,Rosina T. Lis,Xiaoqiu Wu,Edward C. Stack,Edward C. Stack,Massimo Loda,Tao Liu,Han Xu,Laura Cato,James E. Thornton,James E. Thornton,Richard I. Gregory,Richard I. Gregory,Colm Morrissey,Robert L. Vessella,Rodolfo Montironi,Cristina Magi-Galluzzi,Philip W. Kantoff,Steven P. Balk,X. Shirley Liu,Myles Brown +25 more
TL;DR: It is found that the oncogenic function of EZH2 in cells of castration-resistant prostate cancer is independent of its role as a transcriptional repressor, and involves the ability of EzH2 to act as a coactivator for critical transcription factors including the androgen receptor.
Journal ArticleDOI
Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms
Elena Piskounova,Christos Polytarchou,James E. Thornton,James E. Thornton,Robert J. LaPierre,Robert J. LaPierre,Charalabos Pothoulakis,John P. Hagan,Dimitrios Iliopoulos,Richard I. Gregory,Richard I. Gregory +10 more
TL;DR: The results illuminate the distinct mechanisms by which Lin28A and Lin28B function and have implications for the development of new strategies for cancer therapy.
Journal ArticleDOI
How does Lin28 let-7 control development and disease?
TL;DR: This review focuses on current understanding of the Lin28-mediated control of let-7 maturation and highlights the central role of Lin28 in stem cell biology, development, control of glucose metabolism, and dysregulation in human disease.