Haralampos M. Moutsopoulos

TL;DR: Preliminary results from two randomized placebo controlled trials on CD40 blockade and B-cell activating factor receptor receptor inhibition resulted in significant reduction of SS disease activity, with a favorable so far safety profile.

TL;DR: In this article, the authors investigated humoral responses and safety of mRNA SARS-CoV-2 vaccines in systemic autoimmune and autoinflammatory rheumatic disease (SAARD) patients subjected or not to treatment modifications during vaccination.

TL;DR: Patients with early and late disease onset constitute a significant proportion of primary Sjögren’s syndrome population with distinct clinical phenotypes, and possess a higher prevalence of lymphoma, with different predisposing factors and lymphoma distribution across time.

TL;DR: Testing for autoantibodies against both Ro peptides may aim diagnosis, classify clinical manifestations in disease entities and define prognosis in certain autoimmune disorders.

TL;DR: A 70-year-old woman who was diagnosed 5 years ago with cryopyrin-associated periodic syndrome is presented on the basis of her clinical picture, genetic testing which confirmed an NLRP3 missense mutation, and anti-interleukin-1 subcutaneous therapy which resulted in complete resolution of disease signs and symptoms.