Harald G. Foellmer

TL;DR: CD40L is required to induce costimulatory activity on APCs for in vivo activation of CD4+ T cells to produce IFN-γ and to evoke autoimmunity.

TL;DR: A class of nanomaterials endowed with these two signals for rapid optimization of vaccine design with the ability to stimulate two potent innate immune pathways represents a potent new approach to simultaneous antigen and adjuvant delivery.

TL;DR: Results confirm that vaccines designed to coordinately regulate the innate and adaptive immune responses can induce protective immune responses without the need for potentially toxic adjuvants and support the further development of an effective WNV vaccine and novel monovalent and multivalent vaccines for related flaviviruses.

TL;DR: RICHARD E. GALARDYP MARIE E. CASSABONNE, C A R L A ” E GIESE, JAMES H. GILBERT, FRANCE LAPIERRE, HENRY LOPEZ, MARY E. SCHAEFER, ROBERT STACK, MICHAEL SULLIVAN, BRENT SUMMERS, ROB TRESSLER, DAVE TYRRELL, and JENNIFER WEEC

TL;DR: It is demonstrated that Th-2 cytokines increase the resistance of trophoblast cells to Fas-mediated apoptosis either by inhibiting Fas expression or by inducing FLIP activation.