T
Tarek M. Fahmy
Researcher at Yale University
Publications - 165
Citations - 11864
Tarek M. Fahmy is an academic researcher from Yale University. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 49, co-authored 164 publications receiving 10405 citations. Previous affiliations of Tarek M. Fahmy include Johns Hopkins University & DuPont.
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Journal ArticleDOI
Label-free immunodetection with CMOS-compatible semiconducting nanowires
Eric Stern,James F. Klemic,David A. Routenberg,Pauline N. Wyrembak,Daniel B. Turner-Evans,Andrew D. Hamilton,David A. LaVan,Tarek M. Fahmy,Mark A. Reed +8 more
TL;DR: This work reports an approach that uses complementary metal oxide semiconductor (CMOS) field effect transistor compatible technology and hence demonstrates the specific label-free detection of below 100 femtomolar concentrations of antibodies as well as real-time monitoring of the cellular immune response.
Journal ArticleDOI
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
Yun-Hee Youm,Kim Y. Nguyen,Ryan W. Grant,Emily L. Goldberg,Monica Bodogai,Dongin Kim,Dominic P. D’Agostino,Noah J. Planavsky,Christopher R. Lupfer,Thirumala D. Kanneganti,Seokwon Kang,Tamas L. Horvath,Tarek M. Fahmy,Peter A. Crawford,Arya Biragyn,Emad S. Alnemri,Vishwa Deep Dixit +16 more
TL;DR: In vivo, BHB or a ketogenic diet attenuates caspase-1 activation and IL-1β secretion in mouse models of NLRP3-mediated diseases such as Muckle–Wells syndrome, familial cold autoinflammatory syndrome and urate crystal–induced peritonitis and the findings suggest that the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of theNLRP3 inflammasome.
Journal ArticleDOI
Importance of the Debye screening length on nanowire field effect transistor sensors.
TL;DR: The appropriate conditions under which the selective binding of macromolecules is accurately sensed with NW-FET sensors are shown.
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Label-free biomarker detection from whole blood.
Eric Stern,Aleksandar Vacic,Nitin K. Rajan,Jason M. Criscione,Jason Park,Bojan Ilic,David J. Mooney,Mark A. Reed,Tarek M. Fahmy +8 more
TL;DR: This work shows specific and quantitative detection of two model cancer antigens from a 10 uL sample of whole blood in less than 20 minutes and reduces its minimum required sensitivity by effectively pre-concentrating the biomarkers.
Journal ArticleDOI
Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy
Jason Park,Stephen H. Wrzesinski,Stephen H. Wrzesinski,Eric Stern,Michael Look,Jason M. Criscione,Ragy Ragheb,Steven M. Jay,Stacey L. Demento,Atu Agawu,Paula Licona Limon,Anthony F. Ferrandino,David Gonzalez,Ann Habermann,Richard A. Flavell,Richard A. Flavell,Tarek M. Fahmy,Tarek M. Fahmy +17 more
TL;DR: N nanoscale liposomal polymeric gels (nanolipogels; nLGs) of drug-complexed cyclodextrins and cytokine-encapsulating biodegradable polymers that can deliver small hydrophobic molecular inhibitors and water-soluble protein cytokines in a sustained fashion to the tumour microenvironment significantly delayed tumour growth and increased survival of tumour-bearing mice.