H
Harold A. Spurgeon
Researcher at National Institutes of Health
Publications - 107
Citations - 9531
Harold A. Spurgeon is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Myocyte & Diastolic depolarization. The author has an hindex of 52, co-authored 107 publications receiving 9118 citations. Previous affiliations of Harold A. Spurgeon include University of Pittsburgh & Johns Hopkins University.
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Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults.
Kim Sutton-Tyrrell,Samer S. Najjar,Robert M. Boudreau,Lakshmi Venkitachalam,Varant Kupelian,Eleanor M. Simonsick,Richard J. Havlik,Edward G. Lakatta,Harold A. Spurgeon,Stephen B. Kritchevsky,Marco Pahor,Douglas C. Bauer,Anne B. Newman +12 more
TL;DR: Among generally healthy, community-dwelling older adults, aPWV, a marker of arterial stiffness, is associated with higher CV mortality, CHD, and stroke.
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Central or peripheral systolic or pulse pressure: which best relates to target organs and future mortality?
Kang Ling Wang,Hao Min Cheng,Shao Yuan Chuang,Harold A. Spurgeon,Chih Tai Ting,Edward G. Lakatta,Frank C.P. Yin,Pesus Chou,Chen Huan Chen +8 more
TL;DR: Systolic and pulse pressures relate differently to different target organs and central systolic pressure is more valuable than other blood pressure variables in predicting cardiovascular mortality.
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Aortic Stiffness Is Associated With Visceral Adiposity in Older Adults Enrolled in the Study of Health, Aging, and Body Composition
Kim Sutton-Tyrrell,Anne B. Newman,Eleanor M. Simonsick,Richard J. Havlik,Marco Pahor,Edward G. Lakatta,Harold A. Spurgeon,Peter V. Vaitkevicius +7 more
TL;DR: Among older adults, higher levels of visceral fat are associated with greater aortic stiffness as measured by pulse wave velocity, and this association was consistent across tertiles of body weight.
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8-bromo-cGMP reduces the myofilament response to Ca2+ in intact cardiac myocytes.
TL;DR: Analysis of the effects of 8-bromo-cGMP on contraction and simultaneous intracellular Ca2+ transients in intact adult rat ventricular myocytes indicates that cGMP may modulate myocardial relaxation and diastolic tone by reducing the relative myofilament response to Ca2+, probably via cG MP-dependent protein kinase.
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Wave Reflection And Arterial Stiffness In The Prediction Of 15-Year All-Cause And Cardiovascular Mortalities: A Community-Based Study
Kang Ling Wang,Hao Min Cheng,Shih Hsien Sung,Shao Yuan Chuang,Cheng Hung Li,Harold A. Spurgeon,Chih Tai Ting,Samer S. Najjar,Edward G. Lakatta,Frank C.P. Yin,Pesus Chou,Chen Huan Chen +11 more
TL;DR: Pb, a transit time–independent measure of reflected wave magnitude, predicted long-term cardiovascular mortality in men and women independent of arterial stiffness.