H
Harriet Struthers
Researcher at ETH Zurich
Publications - 16
Citations - 1467
Harriet Struthers is an academic researcher from ETH Zurich. The author has contributed to research in topics: Click chemistry & Alkyne. The author has an hindex of 13, co-authored 16 publications receiving 1366 citations. Previous affiliations of Harriet Struthers include Paul Scherrer Institute & University Hospital of Lausanne.
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Metal chelating systems synthesized using the copper(I) catalyzed azide-alkyne cycloaddition.
TL;DR: The areas in which the copper(I) catalyzed azide-alkyne cycloaddition has been applied to the synthesis of novel triazole-containing ligands for transition metals are summarized.
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Site-specific and stoichiometric modification of antibodies by bacterial transglutaminase.
Simone Jeger,Kurt Zimmermann,Alain Blanc,Jürgen Grünberg,Michael Honer,Peter Hunziker,Harriet Struthers,Roger Schibli +7 more
TL;DR: The features of BTG were tested for the preparation of immunoconjugates that are functionalized with different metal chelators and radiolabeled with different diagnostic and therapeutic radionuclides, where low off-target accumulation of radioactivity is crucial.
Journal ArticleDOI
"Click to chelate": synthesis and installation of metal chelates into biomolecules in a single step.
Thomas L. Mindt,Harriet Struthers,Luc Brans,Todor Anguelov,Christian Schweinsberg,Veronique Maes,D. Tourwe,Roger Schibli +7 more
TL;DR: The "click-to-chelate" approach offers a powerful new tool for the modification of (bio)molecules with metal chelators for potential diagnostic and therapeutic applications.
Journal ArticleDOI
“Click-to-Chelate”: Design and Incorporation of Triazole-Containing Metal-Chelating Systems into Biomolecules of Diagnostic and Therapeutic Interest
Harriet Struthers,Harriet Struthers,Bernhard Spingler,Thomas L. Mindt,Roger Schibli,Roger Schibli +5 more
TL;DR: In this paper, the authors used the CuI-catalyzed cycloaddition of azides and terminal alkynes to synthesize novel ligand systems, in which the 1,2,3-triazole is an integral part of the metal chelating system.
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DOTA Conjugate with an Albumin-Binding Entity Enables the First Folic Acid–Targeted 177Lu-Radionuclide Tumor Therapy in Mice
Cristina Müller,Harriet Struthers,Christian Winiger,Konstantin Zhernosekov,Roger Schibli,Roger Schibli +5 more
TL;DR: The modification of a folate radioconjugate with an albumin-binding entity resulted in a significant increase of the tumor-to-kidney ratio of radioactivity, enabling for the first time, to the authors' knowledge, the preclinical application of folic acid–targeted radionuclide therapy in mice.