H
Hathairad Hananantachai
Researcher at Mahidol University
Publications - 45
Citations - 1014
Hathairad Hananantachai is an academic researcher from Mahidol University. The author has contributed to research in topics: Malaria & Cerebral Malaria. The author has an hindex of 18, co-authored 45 publications receiving 950 citations.
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Journal ArticleDOI
Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection.
Jun Ohashi,Jun Ohashi,Izumi Naka,Jintana Patarapotikul,Hathairad Hananantachai,Gary M. Brittenham,Sornchai Looareesuwan,Andrew G. Clark,Katsushi Tokunaga +8 more
TL;DR: The results support the conjecture that the HbE mutation occurred recently, and the allele frequency has increased rapidly, and provide another clear demonstration that a high-resolution LD map across the human genome can detect recent variants that have been subjected to positive selection.
Journal ArticleDOI
CD36 Polymorphism Is Associated with Protection from Cerebral Malaria
Kazuya Omi,Jun Ohashi,Jintana Patarapotikul,Hathairad Hananantachai,Izumi Naka,Sornchai Looareesuwan,Katsushi Tokunaga +6 more
TL;DR: Results of the present study suggest that LD mapping has potential for detecting a disease-associated variant on the basis of haplotype blocks and may be responsible for protection from cerebral malaria in Thailand.
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Fcγ receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria
Kazuya Omi,Jun Ohashi,Jintana Patarapotikul,Hathairad Hananantachai,Izumi Naka,Sornchai Looareesuwan,Katsushi Tokunaga +6 more
TL;DR: The results suggest that FcgammaRIIA-131H/R and FcGammaRIIIB-NA1/NA2 polymorphisms have an interactive effect on host defense against malaria infection.
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Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA.
Kouyuki Hirayasu,Jun Ohashi,Koichi Kashiwase,Hathairad Hananantachai,Izumi Naka,Atsuko Ogawa,Minoko Takanashi,Masahiro Satake,Kazunori Nakajima,Peter Parham,Hisashi Arase,Katsushi Tokunaga,Jintana Patarapotikul,Toshio Yabe +13 more
TL;DR: The results suggest that natural selection has reduced the frequency of the KIR2DL3-HLA-C1 combination in malaria high-endemic populations because of the propensity of interaction between KIR 2DL3 and C1 to favor development of cerebral malaria.
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Significant Association of Longer Forms of CCTTT Microsatellite Repeat in the Inducible Nitric Oxide Synthase Promoter with Severe Malaria in Thailand
Jun Ohashi,Izumi Naka,Jintana Patarapotikul,Hathairad Hananantachai,Sornchai Looareesuwan,Katsushi Tokunaga +5 more
TL;DR: A CCTTT microsatellite repeat in the inducible nitric oxide synthase (iNOS) promoter was analyzed and may play a key role in the pathogenesis of severe malaria.