H
Hayley R. Moore
Researcher at Washington University in St. Louis
Publications - 6
Citations - 540
Hayley R. Moore is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Control of chromosome duplication & DNA replication. The author has an hindex of 5, co-authored 6 publications receiving 479 citations. Previous affiliations of Hayley R. Moore include Brandeis University.
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Journal ArticleDOI
DNA2 drives processing and restart of reversed replication forks in human cells
Saravanabhavan Thangavel,Matteo Berti,Maryna Levikova,Cosimo Pinto,Shivasankari Gomathinayagam,Marko Vujanovic,Ralph Zellweger,Hayley R. Moore,Eu Han Lee,Eric A. Hendrickson,Petr Cejka,Sheila A. Stewart,Massimo Lopes,Alessandro Vindigni +13 more
TL;DR: Following prolonged genotoxic stress, DNA2 and WRN functionally interact to degrade reversed replication forks and promote replication restart, thereby preventing aberrant processing of unresolved replication intermediates.
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Cell cycle synchronization of Escherichia coli using the stringent response, with fluorescence labeling assays for DNA content and replication.
TL;DR: A method for synchronization of the cell cycle in the bacterium Escherichia coli, which can be used in fully wild-type cells, at different growth rates, and may be applicable to other bacterial species with replication control by the stringent response.
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The ObgE/CgtA GTPase influences the stringent response to amino acid starvation in Escherichia coli
TL;DR: It is shown that ObgE binds to pppGpp with biologically relevant affinity in vitro, implicating ppGpp as an in vivo ligand of Obg E, and correlated with DNA replication control under bacterial starvation conditions, suggesting a possible role for the relative balance of these two nucleotides.
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Okazaki Fragment Processing-Independent Role for Human Dna2 Enzyme During DNA Replication
Julien P. Duxin,Hayley R. Moore,Julia M. Sidorova,Kenneth K. Karanja,Yuchi Honaker,Benjamin Dao,Helen Piwnica-Worms,Judith L. Campbell,Raymond J. Monnat,Sheila A. Stewart +9 more
TL;DR: The findings suggest that the genomic instability observed in hDna2-depleted cells does not arise from defective OF maturation and that hDNA2 plays a role in DNA replication that is distinct from FEN1 and Of maturation.
Journal ArticleDOI
Flap endonuclease 1 limits telomere fragility on the leading strand
Daniel C. Teasley,Shankar Parajuli,Mai Nguyen,Hayley R. Moore,Elise Alspach,Ying Jie Lock,Yuchi Honaker,Abhishek Saharia,Helen Piwnica-Worms,Sheila A. Stewart +9 more
TL;DR: It is suggested that FEN1 limits leading strand-specific telomere fragility by processing RNA:DNA hybrid/flap intermediates that arise from co-directional collisions occurring between the replisome and RNA polymerase.