S
Shivasankari Gomathinayagam
Researcher at Baylor University
Publications - 5
Citations - 708
Shivasankari Gomathinayagam is an academic researcher from Baylor University. The author has contributed to research in topics: Helicase & DNA replication. The author has an hindex of 4, co-authored 5 publications receiving 579 citations. Previous affiliations of Shivasankari Gomathinayagam include Saint Louis University.
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Journal ArticleDOI
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition
Matteo Berti,Arnab Ray Chaudhuri,Saravanabhavan Thangavel,Shivasankari Gomathinayagam,Saša Kenig,Marko Vujanovic,Federico Odreman,Timo Glatter,Timo Glatter,Simona Graziano,Ramiro Mendoza-Maldonado,Francesca Marino,Bojana Lucic,Valentina Biasin,Matthias Gstaiger,Matthias Gstaiger,Ruedi Aebersold,Ruedi Aebersold,Ruedi Aebersold,Julia M. Sidorova,Raymond J. Monnat,Massimo Lopes,Alessandro Vindigni +22 more
TL;DR: It is shown that the poly(ADP-ribosyl)ation activity of PARP1 stabilizes forks in the regressed state by limiting their restart by RECQ1, and offers molecular perspectives to potentiate chemotherapeutic regimens based on TOP1 inhibition.
Journal ArticleDOI
DNA2 drives processing and restart of reversed replication forks in human cells
Saravanabhavan Thangavel,Matteo Berti,Maryna Levikova,Cosimo Pinto,Shivasankari Gomathinayagam,Marko Vujanovic,Ralph Zellweger,Hayley R. Moore,Eu Han Lee,Eric A. Hendrickson,Petr Cejka,Sheila A. Stewart,Massimo Lopes,Alessandro Vindigni +13 more
TL;DR: Following prolonged genotoxic stress, DNA2 and WRN functionally interact to degrade reversed replication forks and promote replication restart, thereby preventing aberrant processing of unresolved replication intermediates.
Journal ArticleDOI
Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures
Ashley C. W. Pike,Shivasankari Gomathinayagam,Paolo Swuec,Matteo Berti,Ying Zhang,Christina Schnecke,Francesca Marino,Frank von Delft,Ludovic Renault,Alessandro Costa,Opher Gileadi,Alessandro Vindigni +11 more
TL;DR: The first DNA complex structures, to the authors' knowledge, of the human RECQ1 helicase are determined, which provide new insight into the RecQ helicase mechanism of DNA tracking, strand separation, strand annealing, and Holliday junction (HJ) branch migration.
Journal ArticleDOI
Bacterial DnaB helicase interacts with the excluded strand to regulate unwinding.
TL;DR: The results support the SEW model of unwinding for EcDnaB that expands on the existing SE model of hexameric helicase unwinding to include contributions from the excluded strand to regulate the DNA unwinding rate.
Journal ArticleDOI
Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment.
David R. McKinzey,Shivasankari Gomathinayagam,Wezley C Griffin,Kathleen N. Klinzing,Elizabeth P. Jeffries,Aleksandar Rajkovic,Michael A. Trakselis +6 more
TL;DR: In this article, the authors identify and characterize two unique motifs within the primarily unstructured CTE that are required for localization of MCM8/9 to sites of mitomycin C (MMC)-induced DNA damage.