H
Heather M. Conroe
Researcher at Harvard University
Publications - 4
Citations - 3655
Heather M. Conroe is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Adipogenesis. The author has an hindex of 4, co-authored 4 publications receiving 3280 citations. Previous affiliations of Heather M. Conroe include University of Pennsylvania.
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Journal ArticleDOI
PRDM16 controls a brown fat/skeletal muscle switch
Patrick Seale,Bryan C. Bjork,Wenli Yang,Shingo Kajimura,Sherry Chin,Shihuan Kuang,Anthony Scimè,Srikripa Devarakonda,Heather M. Conroe,Hediye Erdjument-Bromage,Paul Tempst,Michael A. Rudnicki,David R. Beier,Bruce M. Spiegelman +13 more
TL;DR: It is shown by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myogenic lineage.
Journal ArticleDOI
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
Patrick Seale,Heather M. Conroe,Jennifer L. Estall,Shingo Kajimura,Andrea Frontini,Jeff Ishibashi,Paul Cohen,Saverio Cinti,Bruce M. Spiegelman +8 more
TL;DR: It is demonstrated that Prdm16 is a cell-autonomous determinant of a brown fat-like gene program and thermogenesis in subcutaneous adipose tissues and reduced the brown fat phenotype in white adipose tissue stimulated by β-adrenergic agonists.
Journal ArticleDOI
Transcriptional control of preadipocyte determination by Zfp423
Rana K. Gupta,Zoltan Arany,Patrick Seale,Rina J. Mepani,Li Ye,Heather M. Conroe,Yang A. Roby,Heather Kulaga,Randall R. Reed,Bruce M. Spiegelman +9 more
TL;DR: Using a new method for the quantitative analysis of transcriptional components, the zinc-finger protein Zfp423 is identified as a factor enriched in preadipose versus non-preadipose fibroblasts and regulates Pparg expression through amplification of the BMP signalling pathway.
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An Evi1-C/EBPβ Complex Controls Peroxisome Proliferator-Activated Receptor γ2 Gene Expression To Initiate White Fat Cell Differentiation
Jeff Ishibashi,Zeynep Firtina,Sona Rajakumari,Kathleen H. Wood,Heather M. Conroe,David J. Steger,Patrick Seale +6 more
TL;DR: It is shown that the zinc finger protein Evi1 increases in preadipocytes at the onset of differentiation prior to increases in PPARγ levels, indicating that Evi 1 is a key regulator of adipogenic competency.