J
Jennifer L. Estall
Researcher at Université de Montréal
Publications - 58
Citations - 6551
Jennifer L. Estall is an academic researcher from Université de Montréal. The author has contributed to research in topics: Glucose homeostasis & Fatty liver. The author has an hindex of 28, co-authored 50 publications receiving 5660 citations. Previous affiliations of Jennifer L. Estall include Beth Israel Deaconess Medical Center & University Health Network.
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Journal ArticleDOI
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
Patrick Seale,Heather M. Conroe,Jennifer L. Estall,Shingo Kajimura,Andrea Frontini,Jeff Ishibashi,Paul Cohen,Saverio Cinti,Bruce M. Spiegelman +8 more
TL;DR: It is demonstrated that Prdm16 is a cell-autonomous determinant of a brown fat-like gene program and thermogenesis in subcutaneous adipose tissues and reduced the brown fat phenotype in white adipose tissue stimulated by β-adrenergic agonists.
Journal ArticleDOI
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5
Jang Hyun Choi,Alexander S. Banks,Jennifer L. Estall,Shingo Kajimura,Pontus Boström,Dina Laznik,Jorge L. Ruas,Michael J. Chalmers,Theodore M. Kamenecka,Matthias Blüher,Patrick R. Griffin,Bruce M. Spiegelman +11 more
TL;DR: Findings strongly suggest that Cdk5-mediated phosphorylation of PPARγ may be involved in the pathogenesis of insulin-resistance, and present an opportunity for development of an improved generation of anti-diabetic drugs throughPPARγ.
Journal ArticleDOI
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy.
Jorge L. Ruas,James P. White,Rajesh R. Rao,Sandra Kleiner,Kevin T. Brannan,Brooke C. Harrison,Nicholas P. Greene,Jun Wu,Jennifer L. Estall,Brian A. Irving,Ian R. Lanza,Kyle A. Rasbach,Mitsuharu Okutsu,K. Sreekumaran Nair,Zhen Yan,Leslie A. Leinwand,Bruce M. Spiegelman +16 more
TL;DR: A form of PGC-1α (PGC-1 α4) that results from alternative promoter usage and splicing of the primary transcript is identified that regulates and coordinates factors involved in skeletal muscle hypertrophy.
Journal ArticleDOI
Transcriptional control of adipose lipid handling by IRF4.
Jun Eguchi,Xun Wang,Songtao Yu,Erin E. Kershaw,Patricia C. Chiu,Joanne R. Dushay,Jennifer L. Estall,Ulf Klein,Eleftheria Maratos-Flier,Evan D. Rosen +9 more
TL;DR: It is shown that interferon regulatory factor 4 (IRF4) is a critical determinant of the transcriptional response to nutrient availability in adipocytes and the disposition of calories in adipose tissue, with consequences for systemic metabolic homeostasis.
Journal ArticleDOI
β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors
Lee D. Roberts,Pontus Boström,Pontus Boström,John F. O'Sullivan,Robert T. Schinzel,Gregory D. Lewis,Gregory D. Lewis,Andre Dejam,Youn-Kyoung Lee,Melinda J. Palma,Sondra Calhoun,Anastasia Georgiadi,Ming-Huei Chen,Ming-Huei Chen,Vasan S. Ramachandran,Vasan S. Ramachandran,Martin G. Larson,Martin G. Larson,Claude Bouchard,Tuomo Rankinen,Amanda Souza,Clary B. Clish,Thomas J. Wang,Thomas J. Wang,Jennifer L. Estall,Alexander A. Soukas,Chad A. Cowan,Bruce M. Spiegelman,Robert E. Gerszten,Robert E. Gerszten +29 more
TL;DR: In humans, plasma BAIBA concentrations are increased with exercise and inversely associated with metabolic risk factors, and β-aminoisobutyric acid (BAIBA) may contribute to exercise-induced protection from metabolic diseases.