H
Heather M. Moore
Researcher at Genentech
Publications - 29
Citations - 772
Heather M. Moore is an academic researcher from Genentech. The author has contributed to research in topics: Breast cancer & Medicine. The author has an hindex of 9, co-authored 17 publications receiving 559 citations. Previous affiliations of Heather M. Moore include United States Department of the Army & University of Colorado Denver.
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Journal ArticleDOI
Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung.
Daniel Lafkas,Amy L. Shelton,Cecilia Chiu,Gladys de Leon Boenig,Yongmei Chen,Scott Stawicki,Christian Siltanen,Mike Reichelt,Meijuan Zhou,Xiumin Wu,Jeffrey Eastham-Anderson,Heather M. Moore,Meron Roose-Girma,Yvonne Chinn,Julie Q. Hang,Søren Warming,Jackson G. Egen,Wyne P. Lee,Cary D. Austin,Yan Wu,Jian Payandeh,John B. Lowe,Christian W. Siebel +22 more
TL;DR: The discovery that Jagged antagonism relieves a blockade of cell-to-cell conversion unveils unexpected plasticity, and establishes a model for Notch regulation of transdifferentiation.
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EZH2 expands breast stem cells through activation of NOTCH1 signaling
Maria E. Gonzalez,Heather M. Moore,Xin Li,Kathy A. Toy,Wei Huang,Michael S. Sabel,Kelley M. Kidwell,Celina G. Kleer +7 more
TL;DR: This study shows that EZH2 acts as an activator of the NOTCH1 promoter and signaling to expand the stem cell pool, leading to accelerated breast cancer initiation and growth, and uncovers a unique role of EZh2 in activating, rather than repressing, NotCH1 signaling through binding to the Notch1 promoter in TN breast cancer cells.
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A Standardized Discharge Process Decreases Length of Stay for Ventilator-Dependent Children
Christopher D. Baker,Sara Martin,Jodi Thrasher,Heather M. Moore,Joyce Baker,Steven H. Abman,Jason Gien +6 more
TL;DR: Although LOS remained high, a standardized discharge process for chronically ventilated children by an interdisciplinary Ventilator Care Program team resulted in decreased LOS and costs without a negative impact on patient safety.
Journal ArticleDOI
Ultrasonography in the preoperative difficult airway assessment
TL;DR: To evaluate the utility of ultrasound for detection of the difficult intubation in a preoperative setting, PubMed, Ovid, CINAHL Plus Full Text, and Google Scholar searches using [ultrasonography OR sonography OR ultrasound] without date limitations were used.
Journal ArticleDOI
EZH2 inhibition decreases p38 signaling and suppresses breast cancer motility and metastasis.
Heather M. Moore,Maria E. Gonzalez,Kathy A. Toy,Ashley Cimino-Mathews,Pedram Argani,Celina G. Kleer +5 more
TL;DR: It is discovered that knockdown of EZH2 induces a phenotypic reprogramming from mesenchymal to epithelial, reduces motility, and blocks invasion in breast cancer cell lines, and direct evidence that EZh2 inhibition reduces breast cancer metastasis in vivo is provided.