H
Hector Abate
Publications - 21
Citations - 2512
Hector Abate is an academic researcher. The author has contributed to research in topics: Rotavirus vaccine & Pneumonia. The author has an hindex of 10, co-authored 21 publications receiving 2435 citations.
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Journal ArticleDOI
Safety and Efficacy of an Attenuated Vaccine against Severe Rotavirus Gastroenteritis
Guillermo M. Ruiz-Palacios,Irene Pérez-Schael,F. Raúl Velázquez,Hector Abate,Thomas Breuer,Sue Ann Costa Clemens,Brigitte Cheuvart,Felix Espinoza,Paul Gillard,Bruce L. Innis,Yolanda Cervantes,Alexandre da Costa Linhares,Pio Lopez,Mercedes Macias-Parra,Eduardo Ortega-Barria,Vesta Richardson,Doris Maribel Rivera-Medina,Luis Rivera,Belén Salinas,Noris Pavía-Ruz,Jorge Salmerón,Ricardo Rüttimann,Juan Carlos Tinoco,Pilar Rubio,Ernesto Nuñez,M. Lourdes Guerrero,Juan Pablo Yarzabal,Silvia Damaso,Nadia Tornieporth,Xavier Sáez-Llorens,Rodrigo Vergara,Timo Vesikari,Alain Bouckenooghe,Ralf Clemens,Beatrice De Vos,Miguel O'Ryan +35 more
TL;DR: Two oral doses of the live attenuated G1P[8] HRV vaccine were highly efficacious in protecting infants against severe rotavirus gastroenteritis, significantly reduced the rate of severe gastroenteropathy from any cause, and were not associated with an increased risk of intussusception.
Journal ArticleDOI
Efficacy and safety of an oral live attenuated human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in Latin American infants: a randomised, double-blind, placebo-controlled phase III study.
Alexandre da Costa Linhares,F. Raúl Velázquez,Irene Pérez-Schael,Xavier Sáez-Llorens,Hector Abate,Felix Espinoza,Pio Lopez,Mercedes Macias-Parra,Eduardo Ortega-Barria,Doris Maribel Rivera-Medina,Luis Rivera,Noris Pavía-Ruz,Ernesto Nuñez,Silvia Damaso,Guillermo M. Ruiz-Palacios,Beatrice De Vos,Miguel O'Ryan,Paul Gillard,Alain Bouckenooghe +18 more
TL;DR: Two doses of RIX4414 were effective against severe rotavirus gastroenteritis during the first 2 years of life in a Latin American setting and inclusion of Rix4414 in routine paediatric immunisations should reduce the burden of rotav virus gastroEnteritis worldwide.
Journal ArticleDOI
Efficacy of pneumococcal nontypable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in young Latin American children: A double-blind randomized controlled trial.
Miguel Tregnaghi,Xavier Sáez-Llorens,Pio Lopez,Hector Abate,Enrique Smith,Adriana Pósleman,Arlene Calvo,Digna Wong,Carlos Cortes-Barbosa,Ana Ceballos,Marcelo Tregnaghi,Alexandra Sierra,Mirna Rodriguez,Marisol Troitiño,Carlos Carabajal,Andrea Falaschi,Ana Leandro,Maria Mercedes Castrejon,Alejandro Lepetic,Patricia Lommel,William P. Hausdorff,Dorota Borys,Javier Ruiz Guiñazú,Eduardo Ortega-Barria,Juan Pablo Yarzabal,Lode Schuerman +25 more
TL;DR: In a double-blind randomized controlled trial, the vaccine efficacy of PHiD-CV against community-acquired pneumonia in young children in Panama, Argentina, and Columbia is examined.
Journal ArticleDOI
Human Rotavirus Vaccine Is Highly Efficacious When Coadministered With Routine Expanded Program of Immunization Vaccines Including Oral Poliovirus Vaccine in Latin America
Miguel Tregnaghi,Hector Abate,Alejandra Valencia,Pio Lopez,Themis Reverbel da Silveira,Luis Rivera,Doris Maribel Rivera Medina,Xavier Sáez-Llorens,Silvia Elena Gonzalez Ayala,Tirza De Leon,Leen-Jan Van Doorn,Maria Del Pilar Rubio,P.V. Suryakiran,Javier M. Casellas,Eduardo Ortega-Barria,Igor Smolenov,H.H. Han +16 more
TL;DR: RIX4414 was highly efficacious against severe rotav virus gastroenteritis caused by the circulating wild-type rotavirus (G1 and non-G1) when coadministered with routine EPI vaccines including OPV.
Journal ArticleDOI
A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data
Xavier Sáez-Llorens,F. Raúl Velázquez,Pio Lopez,Felix Espinoza,Alexandre da Costa Linhares,Hector Abate,Ernesto Nuñez,Guillermo Venegas V,Rodrigo Vergara,Ana L Jimenez,Maribel Rivera,Carlos Aranza,Vesta Richardson,Mercedes Macias-Parra,Guillermo M Ruiz Palacios,Luis Rivera,Eduardo Ortega-Barria,Yolanda Cervantes,Ricardo Rüttimann,Pilar Rubio,Camilo J. Acosta,Camilo J. Acosta,Claire Newbern,Thomas Verstraeten,Thomas Verstraeten,Thomas Breuer +25 more
TL;DR: The epidemiology and incidence of intussusception in Latin American infants prior to the introduction of new rotavirus vaccines was described and the incidence was found to vary between different countries, as observed in previous studies.