M
Mercedes Macias-Parra
Publications - 8
Citations - 2154
Mercedes Macias-Parra is an academic researcher. The author has contributed to research in topics: Medicine & Rotavirus. The author has an hindex of 4, co-authored 4 publications receiving 2101 citations.
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Journal ArticleDOI
Safety and Efficacy of an Attenuated Vaccine against Severe Rotavirus Gastroenteritis
Guillermo M. Ruiz-Palacios,Irene Pérez-Schael,F. Raúl Velázquez,Hector Abate,Thomas Breuer,Sue Ann Costa Clemens,Brigitte Cheuvart,Felix Espinoza,Paul Gillard,Bruce L. Innis,Yolanda Cervantes,Alexandre da Costa Linhares,Pio Lopez,Mercedes Macias-Parra,Eduardo Ortega-Barria,Vesta Richardson,Doris Maribel Rivera-Medina,Luis Rivera,Belén Salinas,Noris Pavía-Ruz,Jorge Salmerón,Ricardo Rüttimann,Juan Carlos Tinoco,Pilar Rubio,Ernesto Nuñez,M. Lourdes Guerrero,Juan Pablo Yarzabal,Silvia Damaso,Nadia Tornieporth,Xavier Sáez-Llorens,Rodrigo Vergara,Timo Vesikari,Alain Bouckenooghe,Ralf Clemens,Beatrice De Vos,Miguel O'Ryan +35 more
TL;DR: Two oral doses of the live attenuated G1P[8] HRV vaccine were highly efficacious in protecting infants against severe rotavirus gastroenteritis, significantly reduced the rate of severe gastroenteropathy from any cause, and were not associated with an increased risk of intussusception.
Journal ArticleDOI
Efficacy and safety of an oral live attenuated human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in Latin American infants: a randomised, double-blind, placebo-controlled phase III study.
Alexandre da Costa Linhares,F. Raúl Velázquez,Irene Pérez-Schael,Xavier Sáez-Llorens,Hector Abate,Felix Espinoza,Pio Lopez,Mercedes Macias-Parra,Eduardo Ortega-Barria,Doris Maribel Rivera-Medina,Luis Rivera,Noris Pavía-Ruz,Ernesto Nuñez,Silvia Damaso,Guillermo M. Ruiz-Palacios,Beatrice De Vos,Miguel O'Ryan,Paul Gillard,Alain Bouckenooghe +18 more
TL;DR: Two doses of RIX4414 were effective against severe rotavirus gastroenteritis during the first 2 years of life in a Latin American setting and inclusion of Rix4414 in routine paediatric immunisations should reduce the burden of rotav virus gastroEnteritis worldwide.
Journal ArticleDOI
A multi-country study of intussusception in children under 2 years of age in Latin America: analysis of prospective surveillance data
Xavier Sáez-Llorens,F. Raúl Velázquez,Pio Lopez,Felix Espinoza,Alexandre da Costa Linhares,Hector Abate,Ernesto Nuñez,Guillermo Venegas V,Rodrigo Vergara,Ana L Jimenez,Maribel Rivera,Carlos Aranza,Vesta Richardson,Mercedes Macias-Parra,Guillermo M Ruiz Palacios,Luis Rivera,Eduardo Ortega-Barria,Yolanda Cervantes,Ricardo Rüttimann,Pilar Rubio,Camilo J. Acosta,Camilo J. Acosta,Claire Newbern,Thomas Verstraeten,Thomas Verstraeten,Thomas Breuer +25 more
TL;DR: The epidemiology and incidence of intussusception in Latin American infants prior to the introduction of new rotavirus vaccines was described and the incidence was found to vary between different countries, as observed in previous studies.
Journal ArticleDOI
Rotavirus gastroenteritis in Latin America: A hospital-based study in children under 3 years of age
Alexandre da Costa Linhares,Mercedes Macias-Parra,Xavier Sáez-Llorens,Rodrigo Vergara,Elias Jimenez,F. Raúl Velázquez,Yolanda Cervantes,Hector Abate,Luis Rivera,Ricardo Rüttimann,Doris Maribel Rivera-Medina,Belén Salinas,Eduardo Ortega-Barria,Pilar Rubio,Thomas Breuer +14 more
TL;DR: The primary objective of this study was to measure the incidence and disease burden of rotavirus in young children presenting to Latin American hospitals with gastroenteritis, and allowed to setting up the methodology to further conduct a large phase III trial with a rotav virus vaccine in the region.
Journal ArticleDOI
An expert panel opinion on protection against pertussis in Mexico: The role of acellular and whole-cell vaccines.
Agustín De Colsa-Ranero,Mercedes Macias-Parra,Marte Hernández-Porras,Luis Xochihua-Diaz,Arturo Galindo-Fraga,Sarbelio Moreno-Espinosa,Fortino Solórzano-Santos +6 more
TL;DR: International recommendations are presented, and the participants' position is offered regarding the influence of the use of acellular vaccines and the potential disadvantages of reintroducing whole-cell vaccines, mainly due to their reactogenicity.