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Bruce L. Innis
Researcher at GlaxoSmithKline
Publications - 224
Citations - 19219
Bruce L. Innis is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Vaccination & Virus. The author has an hindex of 65, co-authored 218 publications receiving 18242 citations. Previous affiliations of Bruce L. Innis include United States Department of the Army & Chulalongkorn University.
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Journal ArticleDOI
Safety and Efficacy of an Attenuated Vaccine against Severe Rotavirus Gastroenteritis
Guillermo M. Ruiz-Palacios,Irene Pérez-Schael,F. Raúl Velázquez,Hector Abate,Thomas Breuer,Sue Ann Costa Clemens,Brigitte Cheuvart,Felix Espinoza,Paul Gillard,Bruce L. Innis,Yolanda Cervantes,Alexandre da Costa Linhares,Pio Lopez,Mercedes Macias-Parra,Eduardo Ortega-Barria,Vesta Richardson,Doris Maribel Rivera-Medina,Luis Rivera,Belén Salinas,Noris Pavía-Ruz,Jorge Salmerón,Ricardo Rüttimann,Juan Carlos Tinoco,Pilar Rubio,Ernesto Nuñez,M. Lourdes Guerrero,Juan Pablo Yarzabal,Silvia Damaso,Nadia Tornieporth,Xavier Sáez-Llorens,Rodrigo Vergara,Timo Vesikari,Alain Bouckenooghe,Ralf Clemens,Beatrice De Vos,Miguel O'Ryan +35 more
TL;DR: Two oral doses of the live attenuated G1P[8] HRV vaccine were highly efficacious in protecting infants against severe rotavirus gastroenteritis, significantly reduced the rate of severe gastroenteropathy from any cause, and were not associated with an increased risk of intussusception.
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Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial
Diane M. Harper,Eduardo L. Franco,Cosette M. Wheeler,Daron G. Ferris,D. G. Jenkins,Anne Schuind,Toufik Zahaf,Bruce L. Innis,Paulo Naud,Newton Sérgio de Carvalho,Cecilia Roteli-Martins,Julio Cesar Teixeira,Mark M. Blatter,A. Korn,Wim Quint,Gary Dubin +15 more
TL;DR: The bivalent HPV vaccine was efficacious in prevention of incident and persistent cervical infections with HPV-16 and HPV-18, and associated cytological abnormalities and lesions.
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Dengue Viremia Titer, Antibody Response Pattern, and Virus Serotype Correlate with Disease Severity
David W. Vaughn,Sharone Green,Siripen Kalayanarooj,Bruce L. Innis,Suchitra Nimmannitya,Saroj Suntayakorn,Timothy P. Endy,Boonyos Raengsakulrach,Alan L. Rothman,Francis A. Ennis,Ananda Nisalak +10 more
TL;DR: Higher peak titers were associated with increased disease severity for the 31 patients with a peak titer identified, and increased dengue disease severity correlated with high viremia titer, secondary d Dengue virus infection, and DEN-2 virus type.
Journal ArticleDOI
An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis co-circulate.
Bruce L. Innis,Ananda Nisalak,Suchitra Nimmannitya,S. Kusalerdchariya,V. Chongswasdi,Saroj Suntayakorn,P. Puttisri,Charles H. Hoke +7 more
TL;DR: It is proposed that measurement of dengue and Japanese encephalitis IgM and IgG antibodies upon admission and discharge from hospital care should replace the hemagglutination inhibition assay as the standard d Dengue serologic technique in regions where these 2 viruses co-circulate.
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Early Clinical and Laboratory Indicators of Acute Dengue Illness
Siripen Kalayanarooj,David W. Vaughn,S. Nimmannitya,Sharone Green,Saroj Suntayakorn,N. Kunentrasai,W. Viramitrachai,S. Ratanachu-eke,S. Kiatpolpoj,Bruce L. Innis,Alan L. Rothman,A. Nisalak,Francis A. Ennis +12 more
TL;DR: Simple clinical and laboratory parameters are identified that help to identify children with DF or DHF, including plasma AST levels were higher in children who developed DHF than in those with DF.