H
Heike Münzberg
Researcher at Pennington Biomedical Research Center
Publications - 70
Citations - 5402
Heike Münzberg is an academic researcher from Pennington Biomedical Research Center. The author has contributed to research in topics: Leptin & Energy homeostasis. The author has an hindex of 29, co-authored 66 publications receiving 4272 citations.
Papers
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Journal ArticleDOI
Critical roles for the TSC-mTOR pathway in β-cell function
Hiroyuki Mori,Ken Inoki,Darren M. Opland,Heike Münzberg,Eneida C. Villanueva,Miro Faouzi,Tsuneo Ikenoue,David J. Kwiatkowski,Ormond A. MacDougald,Martin G. Myers,Kun-Liang Guan +10 more
TL;DR: In this paper, the role of TSC1 and mTORC1 in β-cell function and glycemic control was investigated in pancreatic β-cells (Rip-Tsc1cKO mice).
Book ChapterDOI
Leptin-signaling pathways and leptin resistance.
TL;DR: This work has shown that leptin acts as an anorexigenic hormone in the brain, where the long form of the leptin receptor (LRb) is widely expressed in hypothalamic and extra-hypothalamic sites that are known to participate in leptin reward pathways.
Journal ArticleDOI
Leptin receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action
Amanda Laque,Yan Zhang,Sarah Gettys,Tu-Anh Nguyen,Kelly Bui,Christopher D. Morrison,Heike Münzberg +6 more
TL;DR: It is confirmed that intra-exPFA leptin injections were indeed sufficient to mediate anorexic responses and speculated that in exPFA Gal-LepRb neurons galanin acts inhibitory rather than orexigenic, based on galan in's known inhibitory function.
Journal ArticleDOI
Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints.
Cristal M. Hill,Thomas Laeger,Diana C. Albarado,David H. McDougal,Hans-Rudolf Berthoud,Heike Münzberg,Christopher D. Morrison +6 more
TL;DR: The F GF21-dependent increase in UCP1 and energy expenditure by LP has no effect on the ability to acutely respond to cold stress, suggesting that LP-induced increases in FGF21 impact metabolic but not thermogenic endpoints.
Journal ArticleDOI
Neural and metabolic regulation of macronutrient intake and selection.
TL;DR: It is suggested that the same basic neural circuitry responsible for the homoeostatic regulation of total energy intake is also used to control consumption of specific macro- and micronutrients.