H
Heini Ijäs
Researcher at Aalto University
Publications - 15
Citations - 518
Heini Ijäs is an academic researcher from Aalto University. The author has contributed to research in topics: DNA origami & DNA nanotechnology. The author has an hindex of 4, co-authored 10 publications receiving 205 citations. Previous affiliations of Heini Ijäs include University of Jyväskylä.
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Journal ArticleDOI
Reconfigurable DNA Origami Nanocapsule for pH-Controlled Encapsulation and Display of Cargo
TL;DR: A DNA origami nanocapsule that can be loaded with cargo and reversibly opened and closed by changing the pH of the surrounding solution is presented and the threshold pH value for opening/closing can be rationally designed.
Journal ArticleDOI
Structural stability of DNA origami nanostructures under application-specific conditions.
TL;DR: The structural stability, denaturation, and degradation of DNA origami nanostructures under different conditions relevant to the fields of biophysics and biochemistry, biomedicine, and materials science, and the methods to improve their stability for desired applications are discussed.
Journal ArticleDOI
Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release
Heini Ijäs,Heini Ijäs,Boxuan Shen,Amelie Heuer-Jungemann,Amelie Heuer-Jungemann,Adrian Keller,Mauri A. Kostiainen,Tim Liedl,Janne A. Ihalainen,Veikko Linko +9 more
TL;DR: In this article, the authors characterize and optimize the DOX loading into different 2D and 3D scaffolded DNA origami nanostructures (DONs), and identify DOX aggregation mechanisms and spectral changes linked to pH, magnesium, and DOX concentration.
Journal ArticleDOI
Dynamic DNA Origami Devices: from Strand-Displacement Reactions to External-Stimuli Responsive Systems.
TL;DR: This review discusses DNA origami nanostructures that exhibit controlled translational or rotational movement when triggered by predefined DNA sequences, various molecular interactions, and/or external stimuli such as light, pH, temperature, and electromagnetic fields.
Posted ContentDOI
Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release
Heini Ijäs,Heini Ijäs,Boxuan Shen,Amelie Heuer-Jungemann,Adrian Keller,Mauri A. Kostiainen,Tim Liedl,Janne A. Ihalainen,Veikko Linko +8 more
TL;DR: Describing and optimizing the DOX loading into different 2D and 3D scaffolded DNA origami nanostructures (DONs) can act as a guide to tailoring the release profiles and developing better drug delivery systems based on DNA-carriers.