H
Heinrich Flaswinkel
Researcher at Ludwig Maximilian University of Munich
Publications - 8
Citations - 877
Heinrich Flaswinkel is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Transgene & Genetically modified mouse. The author has an hindex of 7, co-authored 8 publications receiving 845 citations. Previous affiliations of Heinrich Flaswinkel include Technische Universität München.
Papers
More filters
Journal ArticleDOI
Genome-wide, large-scale production of mutant mice by ENU mutagenesis
M. Hrabe de Angelis,Heinrich Flaswinkel,Helmut Fuchs,Birgit Rathkolb,Dian Soewarto,S. Marschall,Stephan Heffner,Walter Pargent,K. Wuensch,M. Jung,André Reis,Thomas Richter,Francesca Alessandrini,Thilo Jakob,Edith Fuchs,Hubert Kolb,Elisabeth Kremmer,K. Schaeble,B. Rollinski,Adelbert A. Roscher,Christoph Peters,Thomas Meitinger,T. M. Strom,Thomas Steckler,Florian Holsboer,Thomas Klopstock,F. Gekeler,C. Schindewolf,Thomas S. Jung,Karen B. Avraham,Heidrun Behrendt,Johannes Ring,Andreas Zimmer,Klaus Schughart,Klaus Pfeffer,Eckhard Wolf,Rudi Balling +36 more
TL;DR: In screening over 14,000 mice for a large number of clinically relevant parameters, 182 mouse mutants are recovered and this mutagenesis screen leads to a significant increase in the number of mouse models available to the scientific community.
Journal ArticleDOI
Induction of a Senescent-Like Phenotype Does Not Confer the Ability of Bovine Immortal Cells to Support the Development of Nuclear Transfer Embryos
Wei Shi,Andreas Hoeflich,Heinrich Flaswinkel,Miodrag Stojkovic,Eckhard Wolf,Valeri Zakhartchenko +5 more
TL;DR: The results suggest that the developmental failure of donor nuclei from bovine immortal cells could not be reversed by induction of senescent-like phenotype, and the beneficial effect of NaBu on the developmental potential of cloned embryos reconstructed from BFF merits further studies.
Journal ArticleDOI
Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice.
R Zhou,Heinrich Flaswinkel,Marlon R. Schneider,Harald Lahm,Andreas Hoeflich,Ruediger Wanke,Eckhard Wolf +6 more
TL;DR: In conclusion, overexpression of IGFBP-4 inhibits growth of the thymus and is a potential growth inhibitor of lymphoid tissues.
Journal ArticleDOI
Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis
Thilo Jakob,Thilo Jakob,Gabriele Köllisch,Maike Howaldt,M. Bewersdorff,Birgit Rathkolb,Marcel L. Müller,Nadja Sandholzer,Lars Nitschke,Matthias Schiemann,Martin Mempel,Markus Ollert,Antonie Neubauer,Dian Soewarto,Elisabeth Kremmer,Johannes Ring,Heidrun Behrendt,Heinrich Flaswinkel +17 more
TL;DR: Random genome-wide mutagenesis combined with a phenotype screen can be used to generate novel mouse mutants with primary cellular immunodeficiencies, including increased IgE plasma levels.
Journal ArticleDOI
Identification of immunological relevant phenotypes in ENU mutagenized mice.
Heinrich Flaswinkel,Francesca Alessandrini,Birgit Rathkolb,Tanja Decker,Elisabeth Kremmer,Angela Servatius,Thilo Jakob,Dian Soewarto,Susan Marschall,Christiane Fella,Heidrun Behrendt,Johannes Ring,Eckhard Wolf,Rudi Balling,Martin Hrabé de Angelis,Klaus Pfeffer +15 more
TL;DR: High throughput and semi-automated techniques were developed and optimized for low cost per sample and reproducibility and all assays are designed to be nonconsumptive and are based on peripheral blood or direct PCR amplification.