V
Valeri Zakhartchenko
Researcher at Ludwig Maximilian University of Munich
Publications - 113
Citations - 8125
Valeri Zakhartchenko is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Somatic cell nuclear transfer & Blastocyst. The author has an hindex of 44, co-authored 109 publications receiving 7357 citations. Previous affiliations of Valeri Zakhartchenko include University of Nottingham & University of Southern California.
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Journal ArticleDOI
Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos.
Wendy Dean,Fátima Santos,Miodrag Stojkovic,Valeri Zakhartchenko,Jörn Walter,Eckhard Wolf,Wolf Reik +6 more
TL;DR: Mouse embryos undergo genome-wide methylation reprogramming by demethylation in early preimplantation development, followed by remethylation thereafter, and it is shown that epigenetic reprograming occurs aberrantly in most cloned embryos.
Journal ArticleDOI
5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming
Mark Wossidlo,Toshinobu Nakamura,Konstantin Lepikhov,C. Joana Marques,Valeri Zakhartchenko,Michele Boiani,Julia Arand,Toru Nakano,Wolf Reik,Wolf Reik,Jörn Walter +10 more
TL;DR: The data suggest an important role of 5hmC and Tet3 for DNA methylation reprogramming processes in the mammalian zygote, as detected in mouse, bovine and rabbit zygotes.
Journal ArticleDOI
Epigenetic Marking Correlates with Developmental Potential in Cloned Bovine Preimplantation Embryos
Fátima Santos,Valeri Zakhartchenko,Miodrag Stojkovic,Antoine H.F.M. Peters,Thomas Jenuwein,Eckhard Wolf,Wolf Reik,Wendy Dean +7 more
TL;DR: A mechanistic link between DNA and histone methylation in the mammalian embryo is suggested and an association between epigenetic marks and developmental potential of cloned embryos is revealed.
Journal ArticleDOI
Mitochondrial distribution and adenosine triphosphate content of bovine oocytes before and after in vitro maturation: correlation with morphological criteria and developmental capacity after in vitro fertilization and culture.
Miodrag Stojkovic,Sergio Machado,Petra Stojkovic,Valeri Zakhartchenko,Peter Hutzler,Paolo B. Gonçalves,Eckhard Wolf +6 more
TL;DR: The data indicate that mitochondrial reorganization and ATP levels are different between morphologically good and poor oocytes and may be responsible for their different developmental capacity after IVF.
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Consistent success in life-supporting porcine cardiac xenotransplantation
Matthias Längin,Tanja Mayr,Bruno Reichart,Sebastian Michel,Stefan Buchholz,Sonja Guethoff,Alexey Dashkevich,Andrea Baehr,Stefanie Egerer,Andreas Bauer,Maks Mihalj,Alessandro Panelli,Lara Issl,Jiawei Ying,Ann Kathrin Fresch,Ines Buttgereit,Maren Mokelke,Julia Radan,Fabian Werner,I. Lutzmann,Stig Steen,Trygve Sjöberg,Audrius Paskevicius,Liao Qiuming,Riccardo Sfriso,Robert Rieben,Maik Dahlhoff,Barbara Kessler,Elisabeth Kemter,Mayuko Kurome,Valeri Zakhartchenko,Katharina Klett,Katharina Klett,Rabea Hinkel,Rabea Hinkel,Christian Kupatt,Almuth Falkenau,Simone Reu,Reinhard Ellgass,Rudolf Herzog,Uli Binder,Günter Wich,Arne Skerra,David Ayares,Alexander Kind,Uwe Schönmann,Franz-Josef Kaup,Christian Hagl,Eckhard Wolf,Nikolai Klymiuk,Paolo Brenner,Jan-Michael Abicht +51 more
TL;DR: It is shown that α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and thrombomodulin require non-ischaemic preservation with continuous perfusion and post-transplantation growth control to ensure long-term orthotopic function of the xenograft in baboons, the most stringent preclinical xenotransplantation model.