H
Heinz Horstmann
Researcher at Heidelberg University
Publications - 31
Citations - 5182
Heinz Horstmann is an academic researcher from Heidelberg University. The author has contributed to research in topics: Synaptic vesicle & Neurotransmission. The author has an hindex of 20, co-authored 30 publications receiving 4464 citations. Previous affiliations of Heinz Horstmann include Max Planck Society.
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Journal ArticleDOI
Serial block−face scanning electron microscopy to reconstruct three−dimensional tissue nanostructure
Winfried Denk,Heinz Horstmann +1 more
TL;DR: It is demonstrated that datasets meeting these requirements can be obtained by automated block-face imaging combined with serial sectioning inside the chamber of a scanning electron microscope, opening the possibility of automatically obtaining the electron-microscope-level 3D datasets needed to completely reconstruct the connectivity of neuronal circuits.
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Brain tumour cells interconnect to a functional and resistant network
Matthias Osswald,Matthias Osswald,Erik Jung,Erik Jung,Felix Sahm,Felix Sahm,Gergely Solecki,Gergely Solecki,Varun Venkataramani,Jonas Blaes,Jonas Blaes,Sophie Weil,Sophie Weil,Heinz Horstmann,Benedikt Wiestler,Benedikt Wiestler,Benedikt Wiestler,Mustafa Syed,Mustafa Syed,Lulu Huang,Lulu Huang,Miriam Ratliff,Miriam Ratliff,Kianush Karimian Jazi,Kianush Karimian Jazi,Felix T. Kurz,Torsten Schmenger,Torsten Schmenger,Dieter Lemke,Dieter Lemke,Miriam Gömmel,Miriam Gömmel,Martin Pauli,Yunxiang Liao,Yunxiang Liao,Peter Häring,Stefan Pusch,Stefan Pusch,Verena Herl,Christian Steinhäuser,Damir Krunic,Mostafa Jarahian,Hrvoje Miletic,Anna S. Berghoff,Oliver Griesbeck,Georgios Kalamakis,Olga Garaschuk,Matthias Preusser,Samuel Weiss,Hai-Kun Liu,Sabine Heiland,Michael Platten,Michael Platten,Peter E. Huber,Peter E. Huber,Thomas Kuner,Andreas von Deimling,Andreas von Deimling,Wolfgang Wick,Wolfgang Wick,Frank Winkler,Frank Winkler +61 more
TL;DR: It is shown that many tumour cells in astrocytomas extend ultra-long membrane protrusions, and use these distinct tumour microtubes as routes for brain invasion, proliferation, and to interconnect over long distances, which develops functional multicellular network structures.
Journal ArticleDOI
The exocytotic event in chromaffin cells revealed by patch amperometry
Almudena Albillos,Gregor Dernick,Heinz Horstmann,Wolfhard Almers,G. Alvarez de Toledo,Manfred Lindau +5 more
TL;DR: Exocytosis of individual chromaffin granules is investigated by using cell-attached capacitance measurements, combined with electrochemical detection of catecholamines, achieved by inserting a carbon-fibre electrode into the patch pipette and finding that the fusion-pore diameter stays at <3 nm for a variable period, which can last for several seconds, before it expands.
Journal ArticleDOI
Glutamatergic synaptic input to glioma cells drives brain tumour progression
Varun Venkataramani,Varun Venkataramani,Varun Venkataramani,Dimitar Ivanov Tanev,Dimitar Ivanov Tanev,Dimitar Ivanov Tanev,Christopher Strahle,Alexander Studier-Fischer,Alexander Studier-Fischer,Laura Fankhauser,Laura Fankhauser,Tobias Kessler,Tobias Kessler,Christoph Körber,Markus Kardorff,Miriam Ratliff,Ruifan Xie,Ruifan Xie,Heinz Horstmann,Mirko Messer,Mirko Messer,Sang Peter Paik,Johannes Knabbe,Felix Sahm,Felix Sahm,Felix T. Kurz,Azer Aylin Acikgöz,Frank Herrmannsdörfer,Amit Agarwal,Amit Agarwal,Dwight E. Bergles,Anthony J. Chalmers,Hrvoje Miletic,Hrvoje Miletic,Sevin Turcan,Christian Mawrin,Daniel Hänggi,Hai-Kun Liu,Wolfgang Wick,Wolfgang Wick,Frank Winkler,Frank Winkler,Thomas Kuner +42 more
TL;DR: A biologically relevant direct synaptic communication between neurons and glioma cells in different disease models and human tumours is reported: functional bona fide chemical synapses between presynaptic neurons and postsynaptic gliomatic cells.
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Transport, docking and exocytosis of single secretory granules in live chromaffin cells
TL;DR: It is concluded that a large pool of docked granules turns over slowly, that granules move actively to their docking sites, that docking is reversible, and that the ‘rapidly releasable pool’ measured electrophysiologically represents a small subset of docking granules.