T
Thomas Kuner
Researcher at Heidelberg University
Publications - 145
Citations - 9964
Thomas Kuner is an academic researcher from Heidelberg University. The author has contributed to research in topics: Neurotransmission & Synaptic vesicle. The author has an hindex of 51, co-authored 120 publications receiving 8389 citations. Previous affiliations of Thomas Kuner include Karlsruhe Institute of Technology & Max Planck Society.
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Journal ArticleDOI
Control of kinetic properties of AMPA receptor channels by nuclear RNA editing
Hilda Lomelí,Johannes Mosbacher,Thorsten Melcher,Thomas Höger,Jörg R. P. Geiger,Thomas Kuner,Hannah Monyer,Miyoko Higuchi,Bach Alfred,Peter H. Seeburg +9 more
TL;DR: Site-selective nuclear RNA editing controls the calcium permeability of AMPA receptor channels, and RNA editing at a second site is shown here to affect the kinetic aspects of these channels in rat brain.
Journal ArticleDOI
Brain tumour cells interconnect to a functional and resistant network
Matthias Osswald,Matthias Osswald,Erik Jung,Erik Jung,Felix Sahm,Felix Sahm,Gergely Solecki,Gergely Solecki,Varun Venkataramani,Jonas Blaes,Jonas Blaes,Sophie Weil,Sophie Weil,Heinz Horstmann,Benedikt Wiestler,Benedikt Wiestler,Benedikt Wiestler,Mustafa Syed,Mustafa Syed,Lulu Huang,Lulu Huang,Miriam Ratliff,Miriam Ratliff,Kianush Karimian Jazi,Kianush Karimian Jazi,Felix T. Kurz,Torsten Schmenger,Torsten Schmenger,Dieter Lemke,Dieter Lemke,Miriam Gömmel,Miriam Gömmel,Martin Pauli,Yunxiang Liao,Yunxiang Liao,Peter Häring,Stefan Pusch,Stefan Pusch,Verena Herl,Christian Steinhäuser,Damir Krunic,Mostafa Jarahian,Hrvoje Miletic,Anna S. Berghoff,Oliver Griesbeck,Georgios Kalamakis,Olga Garaschuk,Matthias Preusser,Samuel Weiss,Hai-Kun Liu,Sabine Heiland,Michael Platten,Michael Platten,Peter E. Huber,Peter E. Huber,Thomas Kuner,Andreas von Deimling,Andreas von Deimling,Wolfgang Wick,Wolfgang Wick,Frank Winkler,Frank Winkler +61 more
TL;DR: It is shown that many tumour cells in astrocytomas extend ultra-long membrane protrusions, and use these distinct tumour microtubes as routes for brain invasion, proliferation, and to interconnect over long distances, which develops functional multicellular network structures.
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Glutamatergic synaptic input to glioma cells drives brain tumour progression
Varun Venkataramani,Varun Venkataramani,Varun Venkataramani,Dimitar Ivanov Tanev,Dimitar Ivanov Tanev,Dimitar Ivanov Tanev,Christopher Strahle,Alexander Studier-Fischer,Alexander Studier-Fischer,Laura Fankhauser,Laura Fankhauser,Tobias Kessler,Tobias Kessler,Christoph Körber,Markus Kardorff,Miriam Ratliff,Ruifan Xie,Ruifan Xie,Heinz Horstmann,Mirko Messer,Mirko Messer,Sang Peter Paik,Johannes Knabbe,Felix Sahm,Felix Sahm,Felix T. Kurz,Azer Aylin Acikgöz,Frank Herrmannsdörfer,Amit Agarwal,Amit Agarwal,Dwight E. Bergles,Anthony J. Chalmers,Hrvoje Miletic,Hrvoje Miletic,Sevin Turcan,Christian Mawrin,Daniel Hänggi,Hai-Kun Liu,Wolfgang Wick,Wolfgang Wick,Frank Winkler,Frank Winkler,Thomas Kuner +42 more
TL;DR: A biologically relevant direct synaptic communication between neurons and glioma cells in different disease models and human tumours is reported: functional bona fide chemical synapses between presynaptic neurons and postsynaptic gliomatic cells.
Journal ArticleDOI
A genetically encoded ratiometric indicator for chloride: capturing chloride transients in cultured hippocampal neurons.
Thomas Kuner,George J Augustine +1 more
TL;DR: This genetically encoded indicator will permit new approaches ranging from high-throughput drug screening to direct recordings of synaptic Cl- signals in vivo, and suggest that [Cl-]i can signal the location of synaptic activity.
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Maintaining accuracy at the expense of speed: Stimulus similarity defines odor discrimination time in mice
Nixon M. Abraham,Hartwig Spors,Alan Carleton,Troy W. Margrie,Thomas Kuner,Andreas T. Schaefer +5 more
TL;DR: It is concluded that odor discrimination in mice is fast and stimulus dependent, and the underlying neuronal mechanisms act on a fast timescale, requiring only a brief epoch of odor-specific spatiotemporal representations to achieve rapid discrimination of dissimilar odors.