M
Miriam Gömmel
Researcher at German Cancer Research Center
Publications - 5
Citations - 1011
Miriam Gömmel is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Cancer & Vascular permeability. The author has an hindex of 5, co-authored 5 publications receiving 741 citations. Previous affiliations of Miriam Gömmel include University Hospital Heidelberg.
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Journal ArticleDOI
Brain tumour cells interconnect to a functional and resistant network
Matthias Osswald,Matthias Osswald,Erik Jung,Erik Jung,Felix Sahm,Felix Sahm,Gergely Solecki,Gergely Solecki,Varun Venkataramani,Jonas Blaes,Jonas Blaes,Sophie Weil,Sophie Weil,Heinz Horstmann,Benedikt Wiestler,Benedikt Wiestler,Benedikt Wiestler,Mustafa Syed,Mustafa Syed,Lulu Huang,Lulu Huang,Miriam Ratliff,Miriam Ratliff,Kianush Karimian Jazi,Kianush Karimian Jazi,Felix T. Kurz,Torsten Schmenger,Torsten Schmenger,Dieter Lemke,Dieter Lemke,Miriam Gömmel,Miriam Gömmel,Martin Pauli,Yunxiang Liao,Yunxiang Liao,Peter Häring,Stefan Pusch,Stefan Pusch,Verena Herl,Christian Steinhäuser,Damir Krunic,Mostafa Jarahian,Hrvoje Miletic,Anna S. Berghoff,Oliver Griesbeck,Georgios Kalamakis,Olga Garaschuk,Matthias Preusser,Samuel Weiss,Hai-Kun Liu,Sabine Heiland,Michael Platten,Michael Platten,Peter E. Huber,Peter E. Huber,Thomas Kuner,Andreas von Deimling,Andreas von Deimling,Wolfgang Wick,Wolfgang Wick,Frank Winkler,Frank Winkler +61 more
TL;DR: It is shown that many tumour cells in astrocytomas extend ultra-long membrane protrusions, and use these distinct tumour microtubes as routes for brain invasion, proliferation, and to interconnect over long distances, which develops functional multicellular network structures.
Journal ArticleDOI
Tweety-Homolog 1 Drives Brain Colonization of Gliomas.
Erik Jung,Matthias Osswald,Jonas Blaes,Benedikt Wiestler,Felix Sahm,Torsten Schmenger,Gergely Solecki,Katrin Deumelandt,Felix T. Kurz,Ruifan Xie,Sophie Weil,Oliver Heil,Carina M. Thome,Miriam Gömmel,Mustafa Syed,Peter Häring,Peter E. Huber,Peter E. Huber,Sabine Heiland,Michael Platten,Andreas von Deimling,Wolfgang Wick,Frank Winkler +22 more
TL;DR: Targeting of Ttyh1 effectively inhibited the formation of invasive TMs and glioma growth, but increased network formation by intercellular TMs, suggesting a functional and molecular heterogeneity of the recently discovered TMs with potential implications for future TM-targeting strategies.
Journal ArticleDOI
Bevacizumab prevents brain metastases formation in lung adenocarcinoma
Aysegül Ilhan-Mutlu,Matthias Osswald,Yunxiang Liao,Miriam Gömmel,Martin Reck,David Miles,Paola Mariani,Luca Gianni,Beatrix Lutiger,Viktor Nendel,Stefanie Srock,Pablo Perez-Moreno,Frits Thorsen,Louisa von Baumgarten,Matthias Preusser,Wolfgang Wick,Frank Winkler,Frank Winkler +17 more
TL;DR: Treatment with bevacizumab inhibited brain metastases formation and resulted in improved overall survival in a brain-seeking nsNSCLC metastasis model, and no preventive activity could be detected outside the brain.
Journal ArticleDOI
Impact of Blood-Brain Barrier Integrity on Tumor Growth and Therapy Response in Brain Metastases.
Matthias Osswald,Matthias Osswald,Jonas Blaes,Jonas Blaes,Yunxiang Liao,Yunxiang Liao,Gergely Solecki,Gergely Solecki,Miriam Gömmel,Miriam Gömmel,Anna-Sophie Berghoff,Anna-Sophie Berghoff,Laurent Salphati,Jeffrey Wallin,Heidi S. Phillips,Wolfgang Wick,Wolfgang Wick,Frank Winkler,Frank Winkler +18 more
TL;DR: This study provides the first direct evidence that nonpermeable brain micro- and macrometastases can effectively be targeted by a drug designed to cross the BBB, and is a promising agent in preventing or treating brain metastases in patients.
Journal ArticleDOI
Identification and characterization of cancer cells that initiate metastases to the brain and other organs
Anna S. Berghoff,Anna S. Berghoff,Anna S. Berghoff,Yunxiang Liao,Yunxiang Liao,Matthia A. Karreman,Matthia A. Karreman,Ayseguel Ilhan-Mutlu,Katharina Gunkel,Katharina Gunkel,Martin R. Sprick,Christian Eisen,Tobias Kessler,Tobias Kessler,Matthias Osswald,Matthias Osswald,Susanne Wünsche,Susanne Wünsche,Manuel Feinauer,Manuel Feinauer,Brunhilde Gril,Frederic Marmé,Laura Michel,Zuszanna Bago-Horvath,Felix Sahm,Felix Sahm,Natalia Becker,Michael O. Breckwoldt,Gergely Solecki,Gergely Solecki,Miriam Gömmel,Miriam Gömmel,Lulu Huang,Lulu Huang,Petra Rübmann,Carina M. Thome,Miriam Ratliff,Miriam Ratliff,Andreas Trumpp,P. S. Steeg,Matthias Preusser,Wolfgang Wick,Wolfgang Wick,Frank Winkler,Frank Winkler +44 more
TL;DR: The data identify temporary slow-cycling breast cancer cells as the dominant source of brain and other metastases and demonstrates that this can lead to better understanding of BMIC-relevant pathways, including potential new approaches to prevent BM in patients.