The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis &amp; management recommendations for international practice

The Hypertensive Disorders of Pregnancy: The 2021 International Society for the Study of Hypertesion in Pregnancy Classification, Diagnosis & Management Recommendations for International Practice

Preeclampsia complicates 2 to 4% of all pregnancies and accounts for about 46,000 maternal deaths and 500,000 fetal or newborn deaths each year. Antihypertensive agents and magnesium sulfate can help control the systemic manifestations of preeclampsia, which is usually resolved by delivery of the placenta. 

Preeclampsia

Intrahepatic cholestasis of pregnancy is a common disorder of pregnancy manifested by pruritus and elevated bile acids. The etiology of cholestasis is poorly understood and management is difficult due to the paucity of data regarding its diagnosis, treatment, and related adverse outcomes. In this article, we review the epidemiology, pathophysiology, risk factors, laboratory findings, complications, treatment, management, and current evidence surrounding intrahepatic cholestasis of pregnancy.

Helen Cameron

Papers

Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial

Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial